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Isocarboxazid

Catalog No. T4559 CAS 59-63-2

Isocarboxazid has the formula 1-benzyl-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine-isocarboxazid. It is a monoamine oxidase inhibitor.[2] It is used in the treatment of major depression, dysthymic disorder, atypical disorder, panic disorder and the phobic disorders.

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Isocarboxazid, CAS 59-63-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
2 mg	In stock	$ 44.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 176.00
50 mg	In stock	$ 262.00
100 mg	In stock	$ 389.00
500 mg	In stock	$ 883.00
1 mL * 10 mM (in DMSO)	In stock	$ 79.00

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Purity: 99.94%

Purity: 98.78%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Isocarboxazid has the formula 1-benzyl-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine-isocarboxazid. It is a monoamine oxidase inhibitor.[2] It is used in the treatment of major depression, dysthymic disorder, atypical disorder, panic disorder and the phobic disorders.
Targets&IC50	Monoamine oxidase (rat brain):4.8 μM
In vitro	In vivo studies demonstrated isocarboxazid-driven inhibition of MAO in the brain, heart, and liver. The reduced MAO activity, caused by isocarboxazid, results in an increased concentration of serotonin, epinephrine, norepinephrine, and dopamine in storage sites throughout the central nervous system (CNS) and sympathetic nervous system. The increase of one or more monoamines is the basis for the antidepressant activity of MAO inhibitors like isocarboxazid.[1]
In vivo	In vitro studies demonstrated isocarboxazid-driven inhibition of MAO in the brain, heart, and liver. The reduced MAO activity, caused by isocarboxazid, results in an increased concentration of serotonin, epinephrine, norepinephrine, and dopamine in storage sites throughout the central nervous system (CNS) and sympathetic nervous system. The increase of one or more monoamines is the basis for the antidepressant activity of MAO inhibitors like isocarboxazid.[1]

Molecular Weight	231.25
Formula	C12H13N3O2
CAS No.	59-63-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 198.9 mM

References and Literature

1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. 2. Thase ME, Trivedi MH, Rush AJ: MAOIs in the contemporary treatment of depression. Neuropsychopharmacology. 1995 May;12(3):185-219. 3. Kettler R, Da Prada M, Burkard WP: Comparison of monoamine oxidase-A inhibition by moclobemide in vitro and ex vivo in rats. Acta Psychiatr Scand Suppl. 1990;360:101-2.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library NO PAINS Compound Library ReFRAME Related Library Covalent Inhibitor Library Approved Drug Library Reprogramming Compound Library Mitochondria-Targeted Compound Library Antidepressant Compound Library

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MAO-B-IN-19 Obtusin hAChE-IN-3 Bifemelane hydrochloride Safinamide mesylate Pargyline hydrochloride Norharmane MAO-B-IN-22

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Keywords

Isocarboxazid 59-63-2 Neuroscience Monoamine Oxidase inhibit MAO Inhibitor inhibitor

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