Powder: -20°C for 3 years
In solvent: -80°C for 2 years
L-glutamine, a non-essential amino acid, is synthesized from glutamic acid and ammonia.
Description | L-glutamine, a non-essential amino acid, is synthesized from glutamic acid and ammonia. |
In vitro | L-Glutamine (0.2 and 2 mM) but not D-Gln inhibits the generation of L-Arg by both Arg-depleted and nondepleted endothelial cells. L-Glutamine also inhibits the conversion of L-[14C]Cit to L-[14C]Arg by Arg-depleted endothelial cells. L-Glutamine interferes with the conversion of L-Cit to L-Arg probably by acting on argininosuccinate synthetase rather than argininosuccinate lyase. L-Glutamine also inhibits the generation of L-Arg by the monocyte-macrophage cell line J774 but has no effect on the conversion of L-Cit to L-Arg by these cells. [1] L-Glutamine metabolism stimulates Na+-H+exchange of acid-loaded porcine enterocytes by a mechanism not requiring activation of PKC. [2] L-Glutamine (0.2 mM and 2 mM) but not D-glutamine (2 mM), L-glutamic acid (2 mM) or ammonium chloride (1 mM) also inhibits the generation of L-arginine in endothelial cells. [3] L-glutamine promotes chromatin condensation and formation of crescent-like structures in the nucleus of murine primary microglia as well as of the microglial cell-line BV-2. [4] |
In vivo | L-Glutamine at 0.5, 2 and 5 mM dose-dependently reduces H(2)O(2)- or LPS-induced cell death by 14%, 54% and 95%. L-Glutamine increases Glutamine concentrations in small-intestinal lumen and plasma, reduces intestinal expression of Toll-like receptor-4, active caspase-3 and NFkB, ameliorates intestinal injury, decreases rectal temperature, and enhanced growth performance in LPS-challenged piglets. [5] |
Synonyms | L-Glutamic acid 5-amide |
Molecular Weight | 146.14 |
Formula | C5H10N2O3 |
CAS No. | 56-85-9 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: Insoluble
H2O: 10 mM
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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L-Glutamine 56-85-9 Apoptosis Cell Cycle/Checkpoint Metabolism Neuroscience Endogenous Metabolite GluR Ferroptosis LGlutamine Metabotropic glutamate receptors inhibit L-Glutamic acid 5-amide Inhibitor mGluR L Glutamine inhibitor