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Neuroscience GluR L-Glutamine

L-Glutamine

Catalog No. T0326L   CAS 56-85-9
Synonyms: L-Glutamic acid 5-amide

L-glutamine, a non-essential amino acid, is synthesized from glutamic acid and ammonia.

L-Glutamine, CAS 56-85-9
Pack Size Availability Price/USD Quantity
25 mg In stock 35.00
50 mg In stock 44.00
100 mg In stock 55.00
200 mg In stock 66.00
500 mg In stock 90.00
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Purity 99.36%
Biological Description
Chemical Properties
Storage & Solubility Information
Description L-glutamine, a non-essential amino acid, is synthesized from glutamic acid and ammonia.
Targets&IC50 CTP synthase 1
In vitro L-Glutamine (0.2 and 2 mM) but not D-Gln inhibits the generation of L-Arg by both Arg-depleted and nondepleted endothelial cells. L-Glutamine also inhibits the conversion of L-[14C]Cit to L-[14C]Arg by Arg-depleted endothelial cells. L-Glutamine interferes with the conversion of L-Cit to L-Arg probably by acting on argininosuccinate synthetase rather than argininosuccinate lyase. L-Glutamine also inhibits the generation of L-Arg by the monocyte-macrophage cell line J774 but has no effect on the conversion of L-Cit to L-Arg by these cells. [1] L-Glutamine metabolism stimulates Na+-H+exchange of acid-loaded porcine enterocytes by a mechanism not requiring activation of PKC. [2] L-Glutamine (0.2 mM and 2 mM) but not D-glutamine (2 mM), L-glutamic acid (2 mM) or ammonium chloride (1 mM) also inhibits the generation of L-arginine in endothelial cells. [3] L-glutamine promotes chromatin condensation and formation of crescent-like structures in the nucleus of murine primary microglia as well as of the microglial cell-line BV-2. [4]
In vivo L-Glutamine at 0.5, 2 and 5 mM dose-dependently reduces H(2)O(2)- or LPS-induced cell death by 14%, 54% and 95%. L-Glutamine increases Glutamine concentrations in small-intestinal lumen and plasma, reduces intestinal expression of Toll-like receptor-4, active caspase-3 and NFkB, ameliorates intestinal injury, decreases rectal temperature, and enhanced growth performance in LPS-challenged piglets. [5]
Synonyms L-Glutamic acid 5-amide
Purity 99.36%
Molecular Weight 146.14
Formula C5H10N2O3
CAS No. 56-85-9

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

Water: 10 mM

DMSO: Insoluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Sessa WC, et al. Proc Natl Acad Sci U S A,1990, 87(21), 8607-8611. 2. Rhoads JM, et al. Am J Physiol,1994, 266(5 Pt 1), G828-838. 3. Hecker M, et al. Br J Pharmacol,1990, 101(2), 237-239. 4. Svoboda N, et al. Eur J Neurosci,2009, 30(2), 196-206. 5. Haynes TE, et al. Amino Acids,2009, 37(1), 131-142.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Natural Compound Library for HTS Clinical Compound Library Apoptosis Compound Library Neuronal Signaling Compound Library Human Endogenous Metabolite Compound Library FDA-approved Drug Library GPCR Compound Library Anti-Metabolism Disease Compound Library Anti-Cardiovascular Disease Compound Library Anti-cancer Metabolism Compound Library Neurotransmitter Receptor Compound Library FDA Approved & Pharmacopeial Drug Library Glutamine Metabolism Compound Library Mouse Metabolite Compound Library

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