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L-Glutamine

Catalog No. T0326L CAS 56-85-9

Synonyms: L-Glutamic acid 5-amide

L-Glutamine (L-Glutamic acid 5-amide) , a non-essential amino acid, is synthesized from glutamic acid and ammonia.

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L-Glutamine, CAS 56-85-9

Pack Size	Availability	Price/USD	Quantity
5 g	In stock	$ 29.00
1 mL * 10 mM (in H2O)	In stock	$ 50.00

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Purity: 99.36%

Biological Description

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Storage & Solubility Information

Description	L-Glutamine (L-Glutamic acid 5-amide) , a non-essential amino acid, is synthesized from glutamic acid and ammonia.
In vitro	L-Glutamine (0.2 and 2 mM) but not D-Gln inhibits the generation of L-Arg by both Arg-depleted and nondepleted endothelial cells. L-Glutamine also inhibits the conversion of L-[14C]Cit to L-[14C]Arg by Arg-depleted endothelial cells. L-Glutamine interferes with the conversion of L-Cit to L-Arg probably by acting on argininosuccinate synthetase rather than argininosuccinate lyase. L-Glutamine also inhibits the generation of L-Arg by the monocyte-macrophage cell line J774 but has no effect on the conversion of L-Cit to L-Arg by these cells. [1] L-Glutamine metabolism stimulates Na+-H+exchange of acid-loaded porcine enterocytes by a mechanism not requiring activation of PKC. [2] L-Glutamine (0.2 mM and 2 mM) but not D-glutamine (2 mM), L-glutamic acid (2 mM) or ammonium chloride (1 mM) also inhibits the generation of L-arginine in endothelial cells. [3] L-glutamine promotes chromatin condensation and formation of crescent-like structures in the nucleus of murine primary microglia as well as of the microglial cell-line BV-2. [4]
In vivo	L-Glutamine at 0.5, 2 and 5 mM dose-dependently reduces H(2)O(2)- or LPS-induced cell death by 14%, 54% and 95%. L-Glutamine increases Glutamine concentrations in small-intestinal lumen and plasma, reduces intestinal expression of Toll-like receptor-4, active caspase-3 and NFkB, ameliorates intestinal injury, decreases rectal temperature, and enhanced growth performance in LPS-challenged piglets. [5]

Synonyms	L-Glutamic acid 5-amide
Molecular Weight	146.14
Formula	C5H10N2O3
CAS No.	56-85-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Insoluble

H2O: 10 mM

References and Literature

1. Sessa WC, et al. Proc Natl Acad Sci U S A,1990, 87(21), 8607-8611. 2. Rhoads JM, et al. Am J Physiol,1994, 266(5 Pt 1), G828-838. 3. Hecker M, et al. Br J Pharmacol,1990, 101(2), 237-239. 4. Svoboda N, et al. Eur J Neurosci,2009, 30(2), 196-206. 5. Haynes TE, et al. Amino Acids,2009, 37(1), 131-142.

Citations

1. Yang C, Wang X, To K K W, et al.Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis.Signal Transduction and Targeted Therapy.2024, 9(1): 84.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Membrane Protein-targeted Compound Library Human Endogenous Metabolite Library Glutamine Metabolism Compound Library Human Endogenous Metabolite Compound Library Plus Human Metabolite Library Natural Product Library Chinese Pharmacopoeia Natural Product Library Cell Cycle Compound Library Neurotransmitter Receptor Compound Library

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Keywords

L-Glutamine 56-85-9 Apoptosis Metabolism Neuroscience Ferroptosis Endogenous Metabolite GluR L-Glutamic acid 5-amide LGlutamine Metabotropic glutamate receptors inhibit Inhibitor mGluR L-Glutamic acid L Glutamine inhibitor

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