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KCC-07

Catalog No. T8554   CAS 315702-75-1

KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
KCC-07 Chemical Structure
KCC-07, CAS 315702-75-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 34.00
2 mg In stock $ 48.00
5 mg In stock $ 72.00
10 mg In stock $ 126.00
25 mg In stock $ 247.00
50 mg In stock $ 393.00
100 mg In stock $ 585.00
500 mg In stock $ 1,270.00
1 mL * 10 mM (in DMSO) In stock $ 75.00
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Purity: 99.93%
Purity: 98.22%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling.
In vitro In vitro, KCC-07 treatment Medulloblastomas (MB) cells?clearly inhibited MB cell growth, consistent with induction of anti-proliferative BAI1/p53/p21 signaling
Cell Research KCC-07?treatment?Medulloblastomas (MB) cells, Concentration with?10 μM and?Incubation Time with?72 hours
Molecular Weight 269.32
Formula C14H11N3OS
CAS No. 315702-75-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (83.54 mM)

TargetMolReferences and Literature

1. Dan Zhu, et al. BAI1 Suppresses Medulloblastoma Formation by Protecting p53 From Mdm2-Mediated Degradation. Cancer Cell. 2018 Jun 11;33(6):1004-1016.e5.

Related compound libraries

This product is contained In the following compound libraries:
Tyrosine Kinase Inhibitor Library Anti-Cancer Active Compound Library CNS-Penetrant Compound Library Anti-Cancer Compound Library Toxic Compound Library Anti-Lung Cancer Compound Library NO PAINS Compound Library Angiogenesis related Compound Library Inhibitor Library Bioactive Compounds Library Max

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Keywords

KCC-07 315702-75-1 DNA Damage/DNA Repair DNA Alkylator/Crosslinker KCC07 BAI1 p53 inhibit ADGRB1 anticancer Inhibitor MBD2 anti-proliferative ADGR KCC 07 brain-penetrant inhibitor

 

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