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Iguratimod

Catalog No. T5032 CAS 123663-49-0

Synonyms: T614

Iguratimod (T614) is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC50 of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits macrophage migration inhibitory factor (MIF) with an IC50 of 6.81 μM.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Iguratimod, CAS 123663-49-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 43.00
10 mg	In stock	$ 61.00
25 mg	In stock	$ 113.00
50 mg	In stock	$ 207.00
100 mg	In stock	$ 269.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 99.96%

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Description	Iguratimod (T614) is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC50 of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits macrophage migration inhibitory factor (MIF) with an IC50 of 6.81 μM.
Targets&IC50	MIF:6.81μM, COX-2:20μM

Synonyms	T614
Molecular Weight	374.37
Formula	C17H14N2O6S
CAS No.	123663-49-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (26.71 mM)

References and Literature

1. Tanaka K, et al. T-614, a novel antirheumatic drug, inhibits both the activity and induction of cyclooxygenase-2 (COX-2) in cultured fibroblasts. Jpn J Pharmacol. 1995 Apr;67(4):305-14. 2. Sun Y, et al. Anti-rheumatic drug iguratimod protects against cancer-induced bone pain and bone destruction in a rat model. Oncol Lett. 2017 Jun;13(6):4849-4856. 3. Iguratimod, et al. Identification of Iguratimod as an Inhibitor of Macrophage Migration Inhibitory Factor (MIF) with Steroid-sparing Potential. J Biol Chem. 2016 Dec 16;291(51):26502-26514.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Inhibitor Library Angiogenesis related Compound Library Anti-Cardiovascular Disease Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Clinical Compound Library

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Keywords

Iguratimod 123663-49-0 Immunology/Inflammation Neuroscience Others COX Inhibitor Cyclooxygenase inhibit T614 T-614 T 614 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.