Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IKarisoside A(Baohuoside II) is a flavonol glycoside from the Berberidaceae plant Epimedium, with anti-inflammatory activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 90.00 | |
5 mg | In stock | $ 420.00 | |
10 mg | In stock | $ 623.00 | |
25 mg | In stock | $ 993.00 | |
50 mg | In stock | $ 1,330.00 | |
100 mg | In stock | $ 1,780.00 |
Description | IKarisoside A(Baohuoside II) is a flavonol glycoside from the Berberidaceae plant Epimedium, with anti-inflammatory activity. |
In vitro | Ikarisoside A is a natural flavonol glycoside derived from plants of the genus Epimedium, which have been used in Traditional Chinese Medicine as tonics, antirheumatics, and aphrodisiacs. We found that Ikarisoside A (1-100 μM) concentration-dependently inhibited the secretion of catecholamines induced by acetylcholine, a physiological secretagogue and agonist of nicotinic acetylcholine receptors. Ikarisoside A had little effect on catecholamine secretion induced by veratridine and 56 mM K(+). Ikarisoside A (1-100 μM) also inhibited (22)Na(+) influx and (45)Ca(2+) influx induced by acetylcholine in a concentration-dependent manner similar to that of catecholamine secretion. In Xenopus oocytes expressing α3β4 nicotinic acetylcholine receptors, Ikarisoside A (0.1-100 μM) directly inhibited the current evoked by acetylcholine. It also suppressed (14)C-catecholamine synthesis and tyrosine hydroxylase activity induced by acetylcholine at 1-100 μM and 10-100 μM, respectively. The present findings suggest that Ikarisoside A inhibits acetylcholine-induced catecholamine secretion and synthesis by suppression of nicotinic acetylcholine receptor-ion channels in bovine adrenal medullary cells.[1] |
Synonyms | Icarisoside-, Baohuoside II |
Molecular Weight | 500.49 |
Formula | C26H28O10 |
CAS No. | 55395-07-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/ml(228 mM)
Ethanol: 1 mg/ml(1.77 mM)
You can also refer to dose conversion for different animals. More
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IKarisoside A 55395-07-8 Immunology/Inflammation NO Synthase Icarisoside- Baohuoside II inhibitor inhibit