Powder: -20°C for 3 years | In solvent: -80°C for 1 year
5-O-Caffeoylshikimic acid shows anti-oxidative activity; it also shows anti-inflammatory activity, the underlying mechanism was associated with downregulation of nuclear factor-κB.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 116.00 | |
5 mg | In stock | $ 282.00 | |
10 mg | In stock | $ 418.00 | |
25 mg | In stock | $ 695.00 | |
50 mg | In stock | $ 988.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 370.00 |
Description | 5-O-Caffeoylshikimic acid shows anti-oxidative activity; it also shows anti-inflammatory activity, the underlying mechanism was associated with downregulation of nuclear factor-κB. |
In vitro | Cytotoxic activity of saponins and phenolic compounds have been described in the literature, but no reports were found on their multidrug resistance (MDR)-modulating effects on human mdr1 gene-transfected mouse lymphoma cell line.Methylprototribestin, structurally related compounds and a mixture of 3 acetylated isomers of methylprotodioscin were investigated for antiproliferative effect and modulation of drug accumulation. RESULTS: The growth inhibitory dose (ID50) of the compounds ranged from 12.64 to 20.62 mug/ml. Methylprototribestin was the most effective resistance modifier. However, methylprotodioscin, pseudoprotodioscin, prosapogenin A of dioscin, tribestin and 5-O-Caffeoylshikimic acid showed moderate MDR reversal activity. In a checkerboard method, methyloprototribestin and the mixture of the 3 acetylated isomers enhanced the antiproliferative effects on MDR cells in combination with doxorubicin. CONCLUSION: Based on these results, methylprototribestin and the mixture of the 3 acetylated isomers can be recommended for further in vivo experiments in combination with anthracyclines in human MDR-cancer xenograft transplanted mice[1] |
Source |
Molecular Weight | 336.29 |
Formula | C16H16O8 |
CAS No. | 73263-62-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (148.68 mM)
You can also refer to dose conversion for different animals. More
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5-O-Caffeoylshikimic acid 73263-62-4 Apoptosis Immunology/Inflammation TNF IL Receptor NO Synthase inhibit 5 O Caffeoylshikimic acid Inhibitor 5OCaffeoylshikimic acid inhibitor