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HO-3867

Catalog No. T6537 CAS 1172133-28-6

Synonyms: HO3867

HO-3867, an analog of curcumin, is a sspecific STAT3 inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

HO-3867, CAS 1172133-28-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 48.00
2 mg	In stock	$ 70.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 128.00
25 mg	In stock	$ 263.00
50 mg	In stock	$ 422.00
100 mg	In stock	$ 672.00
200 mg	In stock	$ 937.00
1 mL * 10 mM (in DMSO)	In stock	$ 128.00

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Purity: 99%

Purity: 91.18%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	HO-3867, an analog of curcumin, is a sspecific STAT3 inhibitor.
Kinase Assay	Scintillation Proximity Assay, 125I-FGF-2 Binding: SPA protein A beads are supplied as a suspension in PBS at 20 mg/mL, then diluted with binding buffer (KCl, 400 mg/L; MgSO4 200 mg/L; NaCl 6.4 g/L; NaHCO3 3.7 g/L; NaH2PO4 0.141 mg/mL; bis Tris Propane 11.292 g/L; Glucose 4.5 g/L; Gelatin 0.1 %; pH 7.0) at 10 mg/mL. 125I-FGF-2 radioligand and FGFR-1IIIc? - Fc Chimera are diluted into binding buffer. Binding was performed on 96-well plates coated with 0.1 % gelatin. Total assay volume is 0.1 mL. Binding of 125I-FGF-2 is determined by incubation of SPA beads coated with protein A (0.5 mg/assay) with FGFR-1IIIc? - Fc chimera soluble receptor (5 ng/assay), FGF-2 (20 ng/assay) is used for non-specific binding determinations.
Cell Research	Cell viability is determined by a colorimetric assay using MTT. In the mitochondria of living cells, yellow MTT undergoes a reductive conversion to formazan, producing a purple color. Cells, grown to ~80% confluence in 75-mm flasks, are trypsinized, counted, seeded in 96-well plates with an average population of 7,000 cells/well, incubated overnight, and then treated with HO-3867 for 24 h. All experiments are done using 8 replicates and repeated at least three times. (Only for Reference)

Synonyms	HO3867
Molecular Weight	464.55
Formula	C28H30F2N2O2
CAS No.	1172133-28-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 6 mg/mL (12.91 mM), Heating is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 11 mg/mL (23.7 mM)

References and Literature

1. Selvendiran K, et al. Mol Cancer Ther. 2010, 9(5), 1169-1179. 2. Selvendiran K, et al. Cancer Biol Ther. 2011, 12(9), 837-845. 3. Ravi Y, et al. Hypertension. 2013, 61(3), 593-601.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Highly Selective Inhibitor Library Anti-Cancer Active Compound Library Ferroptosis Compound Library Anti-Aging Compound Library Immuno-Oncology Compound Library Bioactive Compound Library Anti-Cancer Metabolism Compound Library Stem Cell Differentiation Compound Library Immunology/Inflammation Compound Library

Related Products

Related compounds with same targets

Salicylic acid JTE-013 ST1074 Kinetin riboside Spautin-1 Bornyl acetate Pyrazoloacridine DMU-212

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

HO-3867 1172133-28-6 Apoptosis JAK/STAT signaling Stem Cells STAT inhibit Inhibitor HO3867 HO 3867 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.