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Ganoderic acid C2

Catalog No. TN1661 CAS 103773-62-2

Ganoderic acid C2 has anti-inflammatory,and anti-tumor-promoting activities. Ganoderic acid C2 can inhibit histamine release, it also has inhibitory effects on the induction of Epstein-Barr Virus early antigen. Ganoderic acid C2 exhibits high inhibitory activity against the rat lens aldose reductase (IC50 = 3.8 µM).

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Ganoderic acid C2, CAS 103773-62-2

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Purity: 98%

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Description	Ganoderic acid C2 has anti-inflammatory,and anti-tumor-promoting activities. Ganoderic acid C2 can inhibit histamine release, it also has inhibitory effects on the induction of Epstein-Barr Virus early antigen. Ganoderic acid C2 exhibits high inhibitory activity against the rat lens aldose reductase (IC50 = 3.8 µM).
Targets&IC50	Aldose reductase:3.8 µM(rat lens)
In vitro	The metabolites and pharmacokinetics of Ganoderic acid C2 (GAC2), a bioactive triterpenoid in Ganoderma lucidum in rat plasma were investigated by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS). Totally, ten minor phase I metabolites of GAC2 were characterized after oral administration of GAC2, on the basis of their mass fragmentation pathways or direct comparison with authentic compounds by high-performance liquid chromatography coupled with diode array detection and electrospray ion trap tandem mass spectrometry (HPLC-DAD-ESI-MS(n)), and liquid chromatography coupled with electrospray ionization hybrid ion trap and time-of-flight mass spectrometry (LC-ESI-IT-TOF/MS) methods. Moreover, a rapid and specific method for quantification of GAC2 in rat plasma after oral administration was developed by using a liquid-liquid extraction procedure and HPLC-ESI-MS/MS analysis.

Molecular Weight	518.68
Formula	C30H46O7
CAS No.	103773-62-2

Storage

store at low temperture,keep away from direct sunlight

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 50 mg/mL (96.40 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Guo XY, et al. Structural characterization of minor metabolites and pharmacokinetics of ganoderic acid C2 in rat plasma by HPLC coupled with electrospray ionization tandem mass spectrometry. J Pharm Biomed Anal. 2013 Mar 5;75:64-73. 2. Fatmawati S, et al. Inhibition of aldose reductase in vitro by constituents of Ganoderma lucidum. Planta Med. 2010 Oct;76(15):1691-3.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ganoderic acid C2 103773-62-2 Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation Metabolism Neuroscience Reductase Immunology/Inflammation related Histamine Receptor Ganoderic acid C-2 Inhibitor Ganoderic acid C 2 inhibit inhibitor

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