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GSK0660

Catalog No. T2674   CAS 1014691-61-2

GSK0660 is an antagonist and inverse agonist of PPARβ/δ.

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GSK0660 Chemical Structure
GSK0660, CAS 1014691-61-2
Pack Size Availability Price/USD Quantity
2 mg In stock $ 39.00
5 mg In stock $ 63.00
10 mg In stock $ 106.00
25 mg In stock $ 195.00
50 mg In stock $ 388.00
100 mg In stock $ 577.00
500 mg In stock $ 1,260.00
1 mL * 10 mM (in DMSO) In stock $ 63.00
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Purity: 100%
Purity: 99.9%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description GSK0660 is an antagonist and inverse agonist of PPARβ/δ.
Targets&IC50 PPAR-β/δ:155 nM
Kinase Assay Human astrocytoma cells, 1321N1, are grown to stably express rat P2X7, human P2X4, P2X2a, P2X2/3, P2X1, P2Y1?and P2Y2 recombinant receptors. Agonist, BzATP, 2,3-O-(4-ben-zoylbenzoyl)-ATP or ATP-induced changes in intracellular Ca2+?concentrations are assessed in all of the cell lines using the Ca2+?chelating dye, Fluo-4, in conjunction with a Fluorometric Imaging Plate Reader. The cells are plated out the day before the experiment onto poly-D-lysine-coated black 96 well plates. After the agonist addition, changes in intracellular Ca2+ concentrations are recorded, per second, for 3 min. Ligands are tested at 11 half-log concentrations from 10-10 to 10-4 M. BzATP or ATP concentrations corresponds to the EC70?values for each receptor to enable comparison of antagonist potencies across the multiple P2 receptor subtypes. A 438079 is added to the cell plate and ?uorescence data are collected for 3 min before the addition of agonist, subsequently, data are then collected for another 2 min. The pEC50 or pIC50 values are derived from a single curve ?t.
Molecular Weight 418.49
Formula C19H18N2O5S2
CAS No. 1014691-61-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 4.18 mg/mL (10 mM)

DMSO: 41.85 mg/mL (100 mM)

TargetMolReferences and Literature

1. Savage SR, et al. Mol Vis. 2015 May 20;21:568-76.

Related compound libraries

This product is contained In the following compound libraries:
Lipid Metabolism Compound Library Anti-Metabolism Disease Compound Library Glycometabolism Compound Library Anti-Alzheimer's Disease Compound Library Anti-Obesity Compound Library NO PAINS Compound Library Anti-Hypertension Compound Library Anti-Cancer Compound Library Anti-Neurodegenerative Disease Compound Library

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Keywords

GSK0660 1014691-61-2 DNA Damage/DNA Repair Metabolism PPAR inhibit Inhibitor GSK 0660 Peroxisome proliferator-activated receptors GSK-0660 inhibitor

 

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