store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 53.00 | |
10 mg | In stock | $ 68.00 | |
25 mg | In stock | $ 117.00 | |
50 mg | In stock | $ 197.00 |
Description | GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling. |
In vitro | GNF-6231 shows IC50s of greater than 10 μM on all CYP isoforms tested[1]. |
In vivo | GNF-6231 has favorable potency and a PK profile across preclinical species upon oral administration. The reference for orally in MMTV-Wnt1 tumor-bearing mice is dosed at 3 mg/kg. GNF-6231 showed very robust dose-related antitumor efficacy[1]. |
Molecular Weight | 448.49 |
Formula | C24H25FN6O2 |
CAS No. | 1243245-18-2 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 36mg/mL (80.3mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
GNF-6231 1243245-18-2 Stem Cells Porcupine GNF 6231 GNF6231 inhibitor inhibit