Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fz7-21 ((Ac)-LPSDDLEFWCHVMY-NH2) is a peptide antagonist of FZD7 . It antagonises WNT3A-induced Wnt-β-catenin signalling in HEK293 expressing FZD7. Fz7-21 impairs Wnt/β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100 nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells (IC50=50 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 89.00 | |
5 mg | In stock | $ 239.00 | |
10 mg | In stock | $ 378.00 | |
25 mg | In stock | $ 628.00 | |
50 mg | In stock | $ 886.00 | |
100 mg | In stock | $ 1,190.00 |
Description | Fz7-21 ((Ac)-LPSDDLEFWCHVMY-NH2) is a peptide antagonist of FZD7 . It antagonises WNT3A-induced Wnt-β-catenin signalling in HEK293 expressing FZD7. Fz7-21 impairs Wnt/β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100 nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells (IC50=50 nM). |
Targets&IC50 | human FZD7 CRD:58 nM (EC50), mouse FZD7 CRD:34 nM (EC50) |
Synonyms | (Ac)-LPSDDLEFWCHVMY-NH2 |
Molecular Weight | 1796.03 |
Formula | C83H114N18O23S2 |
CAS No. | 2247635-23-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mM
You can also refer to dose conversion for different animals. More
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Fz7-21 2247635-23-8 Cytoskeletal Signaling Stem Cells Wnt/beta-catenin lipid-binding groove FZD7 Wnt Fz7 21 (Ac)-LPSDDLEFWCHVMY-NH2 Wnt–β-catenin Fz-7-21 conformation FZD7 CRD intestinal organoids Inhibitor Fz721 inhibit inhibitor