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Fz7-21

Catalog No. TP1263   CAS 2247635-23-8
Synonyms: (Ac)-LPSDDLEFWCHVMY-NH2

Fz7-21 ((Ac)-LPSDDLEFWCHVMY-NH2) is a peptide antagonist of FZD7 . It antagonises WNT3A-induced Wnt-β-catenin signalling in HEK293 expressing FZD7. Fz7-21 impairs Wnt/β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100 nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells (IC50=50 nM).

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Fz7-21 Chemical Structure
Fz7-21, CAS 2247635-23-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 89.00
5 mg In stock $ 239.00
10 mg In stock $ 378.00
25 mg In stock $ 628.00
50 mg In stock $ 886.00
100 mg In stock $ 1,190.00
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Purity: 99.8%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Fz7-21 ((Ac)-LPSDDLEFWCHVMY-NH2) is a peptide antagonist of FZD7 . It antagonises WNT3A-induced Wnt-β-catenin signalling in HEK293 expressing FZD7. Fz7-21 impairs Wnt/β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100 nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells (IC50=50 nM).
Targets&IC50 human FZD7 CRD:58 nM (EC50), mouse FZD7 CRD:34 nM (EC50)
Synonyms (Ac)-LPSDDLEFWCHVMY-NH2
Molecular Weight 1796.03
Formula C83H114N18O23S2
CAS No. 2247635-23-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mM

TargetMolReferences and Literature

1. Nile AH, et al. A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nat Chem Biol. 2018 Sep;14(9):902.

Related compound libraries

This product is contained In the following compound libraries:
Inhibitor Library Peptide Compound Library Neural Regeneration Compound Library Anti-Prostate Cancer Compound Library Anti-Cancer Compound Library Stem Cell Differentiation Compound Library Bioactive Compound Library NO PAINS Compound Library Osteogenesis Compound Library Wnt/Hedgehog/Notch Compound Library

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ISX-9 Wnt pathway activator 2 Wnt/β-catenin agonist 4 F7H KY19382 NRX-252262 FzM1 Carboxylesterase-IN-3

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Keywords

Fz7-21 2247635-23-8 Cytoskeletal Signaling Stem Cells Wnt/beta-catenin lipid-binding groove FZD7 Wnt Fz7 21 (Ac)-LPSDDLEFWCHVMY-NH2 Wnt–β-catenin Fz-7-21 conformation FZD7 CRD intestinal organoids Inhibitor Fz721 inhibit inhibitor

 

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