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Furazolidone

Catalog No. T0751   CAS 67-45-8
Synonyms: Furoxone

Furazolidone (Furoxone), a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM. It is antibacterial and antiprotozoal activity,

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Furazolidone Chemical Structure
Furazolidone, CAS 67-45-8
Pack Size Availability Price/USD Quantity
50 mg In stock $ 30.00
100 mg In stock $ 42.00
500 mg In stock $ 58.00
1 mL * 10 mM (in DMSO) In stock $ 46.00
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Purity: 99.98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Furazolidone (Furoxone), a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM. It is antibacterial and antiprotozoal activity,
Targets&IC50 AML1-ETO:12.7 μM
In vitro Furazolidone displays potent antiproliferative properties at submicromolar concentrations and induces apoptosis in AML cell lines. Furazolidone treatment of certain AML cells induces myeloid cell differentiation by morphology and flow cytometry for CD11b expression, resulting in increased stability of tumor suppressor p53 protein in AML cells[1].
In vivo FZ accelerates its own metabolism in the chicken by induction of the activity of CPR whereas no effect is observed in the rat[2].
Cell Research Leukemic cells are seeded in 96-well culture plates at a density of 1 or 2×104 viable cells/100 µl/well in triplicates and are treated for 24, 48, and 72 hours with an incremental concentration of FZD ranging from 1 µM to 50 µM. Colorimetric CellTiter 96® Aqueous One Solution Cell Proliferation assay is used to determine the cytotoxicity. The optical density at 492 nm is measured using a Multiskan Ascent® microplate photometer. IC50 values are determined by MTS assay when cells are treated with FZD for 72 hours and calculated with GraphPad Prism 5. Each experiment was in triplicate. (Only for Reference)
Synonyms Furoxone
Molecular Weight 225.16
Formula C8H7N3O5
CAS No. 67-45-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 7.5 mg/mL (33.31 mM)

TargetMolReferences and Literature

1. Jiang X, et al. PLoS One. 2013, 8(8):e72335. 2. Nobuo Sasaki, et al. Pesticide Biochemistry and Physiology. 2011, 100(2): 135-139.

TargetMolCitations

1. Lai S, Kumari A, Liu J, et al. Chemical screening reveals Ronidazole is a superior prodrug to Metronidazole for nitroreductase-induced cell ablation system in zebrafish larvae. Journal of Genetics and Genomics. 2021

Related compound libraries

This product is contained In the following compound libraries:
Anti-Parasitic Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library NO PAINS Compound Library Antibiotics Library Neuronal Signaling Compound Library Human Metabolite Library FDA-Approved Drug Library FDA-Approved & Pharmacopeia Drug Library

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Keywords

Furazolidone 67-45-8 Apoptosis Metabolism Microbiology/Virology Neuroscience Antibacterial Antibiotic MAO Inhibitor Bacterial inhibit Furoxone inhibitor

 

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