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Fumagillin

Catalog No. T6841 CAS 23110-15-8

Synonyms: NSC9168, Amebacilin

Fumagillin (Amebacilin) is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to treat microsporidiosis.

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Fumagillin, CAS 23110-15-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 52.00
5 mg	In stock	$ 178.00
10 mg	In stock	$ 355.00
25 mg	In stock	$ 590.00
50 mg	In stock	$ 859.00
100 mg	In stock	$ 1,180.00
500 mg	In stock	$ 2,370.00
1 mL * 10 mM (in DMSO)	In stock	$ 182.00

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Purity: 95%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Fumagillin (Amebacilin) is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to treat microsporidiosis.
In vitro	Fumagillin selectively inhibits the growth of a Δmap1 strain but not a wild-type or a Δmap2 S. cerevisiae strain missing MetAP-2. [1] In budding yeast cells, as a potent inhibitor of angiogenesis, Fumagillin not only reverses the growth inhibitory activity of Vpr, but also inhibits Vpr-dependent viral gene expression upon the infection of human macrophages. [3] Though the toxicity of fumagillin has limited its use for human applications, the analogues using structure-activity relationships relating to its angiogenesis properties may be further explored in the treatment of angiogenesis-dependent diseases. [4]
In vivo	In DEN-treated rats, fumagillin (30 mg/kg, i.p.) inhibits both progression of HCC in the liver itself and systemic metastasis. [2]

Synonyms	NSC9168, Amebacilin
Molecular Weight	458.54
Formula	C26H34O7
CAS No.	23110-15-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 200.6 mM

References and Literature

1. Sin N, et al. Proc Natl Acad Sci U S A. 1997, 94(12), 6099-6103. 2. Sheen IS, et al. World J Gastroenterol. 2005, 11(6), 771-777. 3. Watanabe N, et al. FEBS Lett. 2006, 580(11), 2598-2602. 4. van den Heever JP, et al. J Agric Food Chem. 2014, 62(13), 2728-2737.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Microbial Natural Product Library Inhibitor Library Anti-Parasitic Compound Library Highly Selective Inhibitor Library Antiparasitic Natural Product Library Bioactive Compounds Library Max Approved Drug Library ReFRAME Related Library Natural Product Library for HTS

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Fumagillin 23110-15-8 Microbiology/Virology Others Proteases/Proteasome HIV Protease Parasite Antibiotic inhibit NSC9168 Amebacilin NSC 9168 Human immunodeficiency virus Inhibitor HIV NSC-9168 inhibitor

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