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Finerenone

Catalog No. T21395   CAS 1050477-31-0
Synonyms: BAY948862, BAY-948862, BAY94-8862, BAY 94-8862, BAY-94-8862, BAY 948862

Finerenone (BAY-948862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist with IC50 of 18 nM for the treatment of chronic heart failure. Finerenone (BAY-948862) displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (<500-fold).

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Finerenone Chemical Structure
Finerenone, CAS 1050477-31-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 31.00
5 mg In stock $ 74.00
10 mg In stock $ 116.00
25 mg In stock $ 232.00
50 mg In stock $ 374.00
100 mg In stock $ 597.00
200 mg In stock $ 678.00
500 mg In stock $ 995.00
1 mL * 10 mM (in DMSO) In stock $ 82.00
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Purity: 99.72%
Purity: 99.65%
Purity: 99.45%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Finerenone (BAY-948862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist with IC50 of 18 nM for the treatment of chronic heart failure. Finerenone (BAY-948862) displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold).
Targets&IC50 Mineralocorticoid Receptor:18 nM
Synonyms BAY948862, BAY-948862, BAY94-8862, BAY 94-8862, BAY-94-8862, BAY 948862
Molecular Weight 378.42
Formula C21H22N4O3
CAS No. 1050477-31-0

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (158.55 mM)

H2O: Insoluble

TargetMolReferences and Literature

1. George L Bakris , Rajiv Agarwal ,et al.Effect of Finerenone on Albuminuria in Patients With Diabetic Nephropathy: A Randomized Clinical Trial.JAMA. 2015 Sep 1;314(9):884-94. 2. Bramlage P, Swift SL, Thoenes M, Minguet J, Ferrero C, Schmieder RE. Non-steroidal mineralocorticoid receptor antagonism for the treatment of cardiovascular and renal disease. Eur J Heart Fail. 2016 Jan;18(1):28-37. doi: 10.1002/ejhf.444. Epub 2015 Dec 3. Review. PubMed PMID: 26634965.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Highly Selective Inhibitor Library Orally Active Compound Library Endocrinology-Hormone Compound Library Nuclear Receptor Compound Library Anti-Cancer Compound Library Approved Drug Library Human Metabolite Library

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(20S)-Protopanaxatriol Hydrocortisone hemisuccinate Dicirenone Dexamethasone acetate Mifepristone AZD9567 Medroxyprogesterone Acetate Prednisolone disodium phosphate

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Keywords

Finerenone 1050477-31-0 Endocrinology/Hormones Glucocorticoid Receptor inhibit cardiorenal systolic disease pressure BAY948862 diabetes chronic type BAY-948862 Inhibitor BAY94-8862 kidney BAY 94-8862 BAY-94-8862 Mineralocorticoid Receptor oral nonsteroidal blood BAY 948862 inhibitor

 

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