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Fadrozole hydrochloride

Catalog No. T7556 CAS 102676-31-3

Synonyms: CGS 16949A, 盐酸法倔唑

Fadrozole hydrochloride is a model aromatase inhibitor that has been shown to suppress estrogen production in the ovaries of fish.

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Fadrozole hydrochloride, CAS 102676-31-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Fadrozole hydrochloride is a model aromatase inhibitor that has been shown to suppress estrogen production in the ovaries of fish.
Targets&IC50	Aromatase:1.4 nM (rat), Aromatase:5 nM(human)
In vivo	Fadrozole hydrochloride inhibits growth of androstenedione-stimulated mammary D2 cells implanted into thoracic mammary fat pads of mice by 95% when administered at a dose of 0.5 mg per animal per day.

Synonyms	CGS 16949A, 盐酸法倔唑
Molecular Weight	259.74
Formula	C14H14ClN3
CAS No.	102676-31-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 100 mg/mL (385.02 mM)

H2O: 100 mg/mL (385.02 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Tekmal R R , Durgam V R . A novel in vitro and in vivo breast cancer model for testing inhibitors of estrogen biosynthesis and its action using mammary tumor cells with an activated int-5/aromatase gene[J]. Cancer Letters, 1997, 118(1):0-28.

Related compound libraries

This product is contained In the following compound libraries：

FDA-Approved & Pharmacopeia Drug Library

Related Products

Related compounds with same targets

Eriodictyol chalcone Fadrozole hydrochloride Fadrozole Oleuropein Endoxifen Calceolarioside B Obacunone alpha-Naphthoflavone

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Fadrozole hydrochloride 102676-31-3 内分泌与激素 Aromatase P-450 (Rac)-FAD286 spontaneous tumour Fadrozole Inhibitor Estrogen progesterone inhibit CGS 16949A inhibitor

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