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Ethynodiol diacetate
🥰Excellent
Catalog No. T0996Cas No. 297-76-7
Alias Ethynodiol acetate, 8080 CB
Ethynodiol diacetate (Ethynodiol acetate) is a synthetic progestational hormone utilized alone or combined with estrogens as an oral contraceptive.
Ethynodiol diacetate
🥰Excellent
Purity: 99.54%
Catalog No. T0996Alias Ethynodiol acetate, 8080 CBCas No. 297-76-7
Ethynodiol diacetate (Ethynodiol acetate) is a synthetic progestational hormone utilized alone or combined with estrogens as an oral contraceptive.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 mg | $35 | In Stock | |
| 1 g | $48 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $30 | In Stock |
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CitedSelect Batch
Purity:99.54%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Ethynodiol diacetate (Ethynodiol acetate) is a synthetic progestational hormone utilized alone or combined with estrogens as an oral contraceptive. |
| In vitro | Daily administration of 75 μg of Norgestrel combined with 150 μg of Ethynodiol diacetate and 7.5 μg of Ethinyl estradiol can downregulate plasma concentrations of high-density lipoprotein cholesterol in cynomolgus monkeys. Additionally, a dosage of 6 mg/kg of Ethynodiol diacetate significantly elevates the levels of 3alpha-hydroxy-5alpha-pregnan-20-one and A-homo-3-oxa-5alpha-pregnane-4,20-dione in the urine of female rats, and markedly increases the weight of the rat's pituitary, liver, and kidneys. |
| In vivo | In the presence of an S9 mix, treatment with NDGA inhibits the genotoxic damage induced by Ethynodiol diacetate, which may be attributed to the suppression of cytochrome P450s that prevent the metabolic activation of Ethynodiol diacetate, or due to NDGA's radical scavenging properties. Concurrently, 150 μg/mL Ethynodiol diacetate increases the rate of sister chromatid exchanges and the frequency of chromosomal aberrations in human lymphocytes, and inhibits lymphocyte proliferation. Notably, < 1.5 μM NDGA can reduce the rate of sister chromatid exchanges in human lymphocytes treated with 150 μg/mL Ethynodiol diacetate. |
| Alias | Ethynodiol acetate, 8080 CB |
| Molecular Weight | 384.51 |
| Formula | C24H32O4 |
| Cas No. | 297-76-7 |
| Smiles | [H][C@@]12CC[C@@](OC(C)=O)(C#C)[C@@]1(C)CC[C@]1([H])[C@@]3([H])CC[C@H](OC(C)=O)C=C3CC[C@@]21[H] |
| Relative Density. | 1.0474 g/cm3 (Estimated) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (104.03 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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