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Eprotirome

Catalog No. T5360 CAS 355129-15-6

Synonyms: KB2115

Eprotirome (KB2115), a synthetic thyroid hormone mimetic, is a thyroid hormone receptor agonist.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Eprotirome, CAS 355129-15-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 158.00
2 mg	In stock	$ 233.00
5 mg	In stock	$ 396.00
10 mg	In stock	$ 588.00
25 mg	In stock	$ 939.00
50 mg	In stock	$ 1,260.00
100 mg	In stock	$ 1,680.00
500 mg	In stock	$ 3,420.00

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Purity: 98.29%

Purity: 98.25%

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Description	Eprotirome (KB2115), a synthetic thyroid hormone mimetic, is a thyroid hormone receptor agonist.
In vivo	In moderately overweight and hypercholesterolemic subjects Eprotirome (KB2115) was found to be safe and well tolerated and elicited up to a 40% lowering of total and LDL cholesterol after 14 days of treatment. Bile acid synthesis was stimulated without evidence of increased cholesterol production [1]. KB2115 treated mice exhibited increased fasting glucose, although KB2115 did not increase fasting insulin levels [2].
Animal Research	A catheter was implanted into the right internal jugular vein before the hyperinsulinemic-euglycemic clamp. After recovery, mice were administered GC-1 (0.03 or 0.3 mg/kg), KB2115 (0.3 mg/kg) or T3 (0.06 mg/kg) via intraperitoneal injection for 10 days. On the day of the clamp experiment, conscious, overnight-fasted mice received a primed (10 μCi) and constant rate intravenous infusion (0.1 uCi/min) of [3-3H] glucose to measure basal glucose turnover. After 60–75 minutes of labeled glucose infusion, the hyperinsulinemic-euglycemic clamp was performed with continuous infusion of insulin (12 mU/kg/min) and variable infusion of 25% glucose to maintain euglycemia (~120 mg/dl). Blood samples were collected by tail bleeding (approximately every 10 min) to measure blood glucose concentrations [2].

Synonyms	KB2115
Molecular Weight	487.14
Formula	C18H17Br2NO5
CAS No.	355129-15-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 30 mg/mL

DMSO: 90 mg/mL (184.75 mM)

References and Literature

1. Berkenstam A, et al. The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):663-7. 2. Martagón AJ, et al. The amelioration of hepatic steatosis by thyroid hormone receptor agonists is insufficient to restore insulin sensitivity in ob/ob mice. PLoS One. 2015 Apr 7;10(4):e201221987.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Obesity Compound Library Clinical Compound Library ReFRAME Related Library NO PAINS Compound Library Bioactive Compound Library Nuclear Receptor Compound Library Bioactive Compounds Library Max Endocrinology-Hormone Compound Library Anti-Metabolism Disease Compound Library

Related Products

Related compounds with same targets

Methimazole L-Thyroxine CO23 TR antagonist 1 Liothyronine sodium DPC AJ1951 acetate Liothyronine Protirelin Acetate

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Keywords

Eprotirome 355129-15-6 Endocrinology/Hormones Thyroid hormone receptor(THR) THR inhibit KB 2115 Inhibitor KB-2115 KB2115 Thyroid Hormone Receptor inhibitor

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