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Eprosartan Mesylate

Name: Eprosartan Mesylate
Brand: TargetMol
SKU: T2531
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2531Cas No. 144143-96-4

Alias SKF-108566J

Eprosartan Mesylate (SKF-108566J) is a competitive and reversible Angiotensin II Receptor Blocker.

Eprosartan Mesylate

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Purity: 99.93%

Catalog No. T2531Alias SKF-108566JCas No. 144143-96-4

Eprosartan Mesylate (SKF-108566J) is a competitive and reversible Angiotensin II Receptor Blocker.

Pack Size	Price	Availability
10 mg	$40	In Stock
25 mg	$63	In Stock
50 mg	$77	In Stock
100 mg	$112	In Stock
200 mg	$173	In Stock
500 mg	$292	In Stock
1 mL x 10 mM (in DMSO)	$40	In Stock

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Purity:99.93%

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COA

Product Introduction

Bioactivity

Description	Eprosartan Mesylate (SKF-108566J) is a competitive and reversible Angiotensin II Receptor Blocker.
Targets&IC50	AT1 receptor:0.83 nM(Kd)
In vitro	In a study involving brain and spinal cord injured rats, Eprosartan (0.3 mg/kg i.v.) was observed to induce a hypertensive response following spinal cord stimulation.
In vivo	Eprosartan effectively inhibits [125I]-Angiotensin II in human tissues (adrenal cortex, liver, cloned AT1 receptors) with an IC50 range of 1.4-3.9 nM and in rat tissues (mesenteric artery, adrenal cortex, glomeruli) with an IC50 range of 1.5-9.2 nM. In isolated perfused proximal tubules of rabbits, Eprosartan (100 nM) completely blocks the isosmotic fluid absorption induced by Angiotensin II.
Synonyms	SKF-108566J

Chemical Properties

Molecular Weight	520.62
Formula	C₂₃H₂₄N₂O₄S·CH₄O₃S
Cas No.	144143-96-4
Smiles	s1c(C/C(=C\c2n(c(nc2)CCCC)Cc2ccc(cc2)C(=O)O)/C(=O)O)ccc1.S(=O)(=O)(O)C
Relative Density.	1.26 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 4 mg/mL (7.68 mM), Sonication is recommended.

DMSO: 104 mg/mL (199.76 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9208 mL	9.6039 mL	19.2079 mL	96.0393 mL
5 mM	0.3842 mL	1.9208 mL	3.8416 mL	19.2079 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.1921 mL	0.9604 mL	1.9208 mL	9.6039 mL
20 mM	0.0960 mL	0.4802 mL	0.9604 mL	4.8020 mL
50 mM	0.0384 mL	0.1921 mL	0.3842 mL	1.9208 mL
100 mM	0.0192 mL	0.0960 mL	0.1921 mL	0.9604 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc