Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07, 6.03 and 8.55 μM).
Description | Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07, 6.03 and 8.55 μM). |
Targets&IC50 | BChE:6.03 µM, BACE1:8.55 μM, AChE:1.07 µM |
In vitro | Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO- scavenging effect (IC50, 16.83 μM), and may protect against Alzheimer disease[1]. Epiberberine (0, 12.5, 25, or 50 μM) dose-dependently inhibits cellular triglyceride accumulation in 3T3-L1 adipocytes (IC50: 52.8 μM). Epiberberine (12.5-50 μM) suppresses the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways in the early stage of 3T3-L1 adipocyte differentiation [2]. Epiberberine (0.2, 1, 5 μg/mL) inhibits glucose uptake in HepG2 cells in a concentration-dependent manner [3]. |
In vivo | Body weight, food consumption, water intake, and urinary output of KK-Ay mice were reduced after being treated with Epiberberine (225 mg/kg, p.o. daily for 40 days). |
Synonyms | 盐酸表小檗碱, Epiberberine (chloride), 表小檗碱氯化物 |
Molecular Weight | 371.82 |
Formula | C20H18ClNO4 |
CAS No. | 889665-86-5 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 7.4 mg/mL (19.9 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Epiberberine chloride 889665-86-5 NF-Kb信号通路 代谢 免疫与炎症 神经科学 AChE AChR BACE Beta-Secretase Reactive Oxygen Species Epiberberine (chloride) Cholinesterase (ChE) inhibit β-Secretase Epiberberine Inhibitor Beta-secretase inhibitor