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Epiberberine chloride

Catalog No. T8306 CAS 889665-86-5

Synonyms: 盐酸表小檗碱, Epiberberine (chloride), 表小檗碱氯化物

Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07, 6.03 and 8.55 μM).

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Epiberberine chloride, CAS 889665-86-5

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07, 6.03 and 8.55 μM).
Targets&IC50	BChE:6.03 µM, BACE1:8.55 μM, AChE:1.07 µM
In vitro	Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO- scavenging effect (IC50, 16.83 μM), and may protect against Alzheimer disease[1]. Epiberberine (0, 12.5, 25, or 50 μM) dose-dependently inhibits cellular triglyceride accumulation in 3T3-L1 adipocytes (IC50: 52.8 μM). Epiberberine (12.5-50 μM) suppresses the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways in the early stage of 3T3-L1 adipocyte differentiation [2]. Epiberberine (0.2, 1, 5 μg/mL) inhibits glucose uptake in HepG2 cells in a concentration-dependent manner [3].
In vivo	Body weight, food consumption, water intake, and urinary output of KK-Ay mice were reduced after being treated with Epiberberine (225 mg/kg, p.o. daily for 40 days).

Synonyms	盐酸表小檗碱, Epiberberine (chloride), 表小檗碱氯化物
Molecular Weight	371.82
Formula	C20H18ClNO4
CAS No.	889665-86-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 7.4 mg/mL (19.9 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Jung HA, et al. Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids. Biol Pharm Bull. 2009 Aug;32(8):1433-8. 2. Choi JS, et al. Anti-adipogenic effect of epiberberine is mediated by regulation of the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways. Arch Pharm Res. 2015 Dec;38(12):2153-62. 3. Ma H, et al. Antihyperglycemia and Antihyperlipidemia Effect of Protoberberine Alkaloids From Rhizoma Coptidis in HepG2 Cell and Diabetic KK-Ay Mice. Drug Dev Res. 2016 Jun;77(4):163-70.

Related Products

Related compounds with same targets

Methyl tridecanoate Vincosamide Arjunolic acid Epiberberine chloride AChE-IN-26 AChE/BChE-IN-10 Jatrorrhizine chloride 1-Naphthyl acetate

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Epiberberine chloride 889665-86-5 NF-Kb信号通路代谢免疫与炎症神经科学 AChE AChR BACE Beta-Secretase Reactive Oxygen Species Epiberberine (chloride) Cholinesterase (ChE) inhibit β-Secretase Epiberberine Inhibitor Beta-secretase inhibitor

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