Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Eletriptan hydrobromide (Eletriptan HBr) is an orally active agonist with specific affinity for the 5-hydroxytriptamine1B/1D receptor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 33.00 | |
5 mg | In stock | $ 52.00 | |
10 mg | In stock | $ 64.00 | |
25 mg | In stock | $ 136.00 | |
50 mg | In stock | $ 247.00 | |
100 mg | In stock | $ 450.00 | |
200 mg | In stock | $ 585.00 | |
500 mg | In stock | $ 937.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 57.00 |
Description | Eletriptan hydrobromide (Eletriptan HBr) is an orally active agonist with specific affinity for the 5-hydroxytriptamine1B/1D receptor. |
Targets&IC50 | 5-HT1B:0.92 nM(Ki), 5-HT1D:3.14 nM(Ki) |
In vitro | [3H]Eletriptan has a total number of binding sites (Bmax) of 2478 fmol/mg and 1576 fmol/mg for 5-HT1B and 5-HT1D, respectively. [3H]Eletriptan has a significantly faster association rate (K(on) 0.249/min/nM) than [3H]sumatriptan (K(on) 0.024/min/nM) and a significantly slower off-rate (K(off) 0.027/min compared to 0.037/min for [3H]sumatriptan). [1] Eletriptan induces concentration-dependent contractions of meningeal artery, coronary artery, and saphenous vein. The potency of Eletriptan is higher in meningeal artery than in coronary artery (86-fold) or saphenous vein (66-fold). The predicted contraction by Eletriptan (40 mg and 80 mg) and sumatriptan (100 mg) at free C(max) observed in clinical trials is similar in meningeal artery. [2] |
Synonyms | Eletriptan HBr, UK-116044 |
Molecular Weight | 463.43 |
Formula | C22H27BrN2O2S |
CAS No. | 177834-92-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 46.3 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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Eletriptan hydrobromide 177834-92-3 GPCR/G Protein Neuroscience 5-HT Receptor Inhibitor Eletriptan Hydrobromide Eletriptan 5-hydroxytryptamine Receptor Eletriptan HBr UK 116044 UK116044 inhibit UK-116044 Serotonin Receptor inhibitor