Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EC330, a novel steroidal LIF inhibitor showed cytotoxicity in various cancer cell lines and NCI-60 cell line panel at low nano-molar range.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 85.00 | |
5 mg | In stock | $ 247.00 | |
10 mg | In stock | $ 352.00 | |
25 mg | In stock | $ 595.00 | |
50 mg | In stock | $ 848.00 | |
100 mg | In stock | $ 1,170.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 282.00 |
Description | EC330, a novel steroidal LIF inhibitor showed cytotoxicity in various cancer cell lines and NCI-60 cell line panel at low nano-molar range. |
In vitro | EC330 blocked formation of colonies in soft agar and inhibited angiogenesis (tube formation) in human umbilical vein endothelial cells. EC330 binds to LIF/LIFR complex by insilico docking studies and reduced the STAT3 phosphorylation in a dose dependent manner through blocking LIF-JAK-STAT signaling. EC330 showed marked specificity in MCF-7 cells overexpressing LIF verses MCF-7 cells. The compound further showed cytoskeletal disruption and targeting cancer associated fibroblasts (CAFs). |
In vivo | EC330 treatment (0.5 and 2.5mg/kg) dose dependently reduced tumor burden in ovarian (IGROV-1) and triple negative breast cancer (MDA-MB-231) cell xenografted mouse models. |
Molecular Weight | 462.57 |
Formula | C30H32F2O2 |
CAS No. | 2016795-77-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 20 mg/mL (43.24 mM)
You can also refer to dose conversion for different animals. More
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EC330 2016795-77-8 Others EC-330 EC 330 inhibit Inhibitor inhibitor