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Dirithromycin

Name: Dirithromycin
Brand: TargetMol
SKU: T0971
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0971Cas No. 62013-04-1

Alias LY237216, Diritromicina, Dirithromycinum, Dirithromycine, ASE 136

Dirithromycin (LY237216) is a macrolide glycopeptide antibiotic. It is used to treat many different types of bacterial infections, such as bronchitis, pneumonia, tonsillitis, and even skin infections.

Dirithromycin

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Purity: 98.89%

Catalog No. T0971Alias LY237216, Diritromicina, Dirithromycinum, Dirithromycine, ASE 136Cas No. 62013-04-1

Pack Size	Price	Availability	Quantity
500 mg	$31	In Stock
1 g	$48	In Stock

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Batch Information

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Purity:98.89%

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Bioactivity

Description	Dirithromycin (LY237216) is a macrolide glycopeptide antibiotic. It is used to treat many different types of bacterial infections, such as bronchitis, pneumonia, tonsillitis, and even skin infections.
In vivo	At therapeutic concentrations, Dirithromycin enhances the production of IL1β in cells stimulated by lipopolysaccharides, with increases of +37% and +28% at 1 μg/mL. At supra-therapeutic concentrations, Dirithromycin inhibits IL1β through the inhibition of protein kinase C; the concentration of Dirithromycin when 50% inhibition is achieved is 378 mg/mL, while for Spiramycin it is 234 mg/mL.
Synonyms	LY237216, Diritromicina, Dirithromycinum, Dirithromycine, ASE 136

Chemical Properties

Molecular Weight	835.07
Formula	C₄₂H₇₈N₂O₁₄
Cas No.	62013-04-1
Smiles	C[C@@H]1[C@]2(O[C@H](COCCOC)N[C@]1([C@H](C)C[C@@](C)(O)[C@H](O[C@H]3[C@H](O)[C@@H](N(C)C)C[C@@H](C)O3)[C@@H](C)[C@H](O[C@H]4C[C@](OC)(C)[C@@H](O)[C@H](C)O4)[C@@H](C)C(=O)O[C@H](CC)[C@@]2(C)O)[H])[H]
Relative Density.	1.19 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 2.09 mg/mL (2.5 mM), Sonication is recommended.

Ethanol: 93 mg/mL (111.37 mM), Sonication is recommended.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	1.1975 mL	5.9875 mL	11.9750 mL	59.8752 mL

Ethanol

	1mg	5mg	10mg	50mg
5 mM	0.2395 mL	1.1975 mL	2.3950 mL	11.9750 mL
10 mM	0.1198 mL	0.5988 mL	1.1975 mL	5.9875 mL
20 mM	0.0599 mL	0.2994 mL	0.5988 mL	2.9938 mL
50 mM	0.0240 mL	0.1198 mL	0.2395 mL	1.1975 mL
100 mM	0.0120 mL	0.0599 mL	0.1198 mL	0.5988 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc