Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Diphenmanil methylsulfate (Diphemanil mesylate), a quaternary ammonium anticholinergic, binds muscarinic acetylcholine receptors and thus decreases secretory excretion of stomach acids, sweat, and saliva.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 40.00 | |
25 mg | In stock | $ 63.00 | |
50 mg | In stock | $ 79.00 | |
100 mg | In stock | $ 103.00 | |
200 mg | In stock | $ 151.00 | |
500 mg | In stock | $ 249.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Diphenmanil methylsulfate (Diphemanil mesylate), a quaternary ammonium anticholinergic, binds muscarinic acetylcholine receptors and thus decreases secretory excretion of stomach acids, sweat, and saliva. |
In vitro | Pharmacokinetic studies indicate that Diphemanil Methylsulphate is slowly absorbed, with a peak time (tmax) of 2-4 hours and an average half-life of 8.35 hours. Within 48 hours, 0.6%-7.4% of the administered dose is recovered in the urine. The compound exhibits poor gastrointestinal absorption, with bioavailability ranging from 15% to 25%. |
In vivo | Diphemanil Methylsulfate exerts its anticholinergic effects primarily by binding to muscarinic M3 receptors, and it also acts directly on smooth muscle to provide antispasmodic benefits. |
Synonyms | Diphemanil mesylate, Diphemanil Methylsulfate |
Molecular Weight | 389.51 |
Formula | C20H24N·CH3O4S |
CAS No. | 62-97-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 24 mg/mL (61.6 mM)
H2O: 26 mg/mL (66.8 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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