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Dimethyl sulfone

Name: Dimethyl sulfone
Brand: TargetMol
SKU: TN6752
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN6752Cas No. 67-71-0

Dimethyl sulfone exists in all living organisms, ranging from bacteria to humans. It derives from dietary sources, from intestinal bacterial metabolism and from human endogenous methanethiol metabolism. Dimethyl sulfone is a metabolite occurring in plasma and CSF of normal human.

Dimethyl sulfone

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Catalog No. TN6752Cas No. 67-71-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:≥98%

Appearance:Solid

Color:White

Resource Download

COA HNMR

Product Introduction

Dimethyl sulfone AI Summary

Dimethyl sulfone demonstrates a range of bioactivities, including the inhibition of acetylcholinesterase hydrolysis of acetylcholine with reversible inhibition constants (Ki) of 28,000,000.0 nM (competitive) and 260,000,000.0 nM (noncompetitive). It exhibits cytotoxic activity against several cancer cell lines such as human cervical carcinoma, human melanoma, DNA cross-linking resistant human ovarian carcinoma, and highly melanated human melanoma, with IC50 values between 35.0 uM and 59.0 uM. Additionally, Dimethyl sulfone shows significant inhibitory effects on human Jumonji domain containing 2E (JMJD2E) and Cytochrome P450 3A4, and exhibits moderate potency in interfering with CBF-beta and RUNX1 interaction, potentially aiding in Acute Myeloid Leukemia treatment. The compound also inhibits sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells at 10 uM, with inhibition percentages of 102.71% and 115.06%, respectively, indicating its role in modulating OATP transport functions. Furthermore, it inhibits MANT-uracil binding to various isoforms of cereblon protein across multiple organisms, with IC50 values ranging from 10,000,000 nM to 737,000,000 nM and Ki values from 5,690,000 nM to 664,460,000 nM. Finally, the compound shows a high binding affinity to AT1 receptors in the rabbit aorta, with an IC50 of 2.6 nM, which suggests potential vascular system modulating capabilities..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	94.13
Formula	C₂H₆O₂S
Cas No.	67-71-0
Smiles	S(C)(C)(=O)=O
Relative Density.	0.821 g/cm3. Temperature:28.5 °C.;0.856 g/cm3. Temperature:28.5 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (531.18 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	10.6236 mL	53.1180 mL	106.2361 mL	531.1803 mL
5 mM	2.1247 mL	10.6236 mL	21.2472 mL	106.2361 mL
10 mM	1.0624 mL	5.3118 mL	10.6236 mL	53.1180 mL
20 mM	0.5312 mL	2.6559 mL	5.3118 mL	26.5590 mL
50 mM	0.2125 mL	1.0624 mL	2.1247 mL	10.6236 mL
100 mM	0.1062 mL	0.5312 mL	1.0624 mL	5.3118 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc