Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Diflunisal (Dolobid) is a cyclooxygenase (COX) Inhibitor, used as an anti-inflammatory analgesic.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 30.00 | |
50 mg | In stock | $ 43.00 | |
100 mg | In stock | $ 61.00 | |
200 mg | In stock | $ 89.00 | |
500 mg | In stock | $ 148.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Diflunisal (Dolobid) is a cyclooxygenase (COX) Inhibitor, used as an anti-inflammatory analgesic. |
Targets&IC50 | p300:996 μM |
In vitro | Diflunisal, an FDA-approved drug containing a salicylic acid substructure, inhibited CBP/p300 more potently than salicylate. Diflunisal exhibits anti-tumor activity against a specific leukemia carrying a t(8;21) translocation, a tumor previously reported to be dependent on p300 in vitro and in vivo[2]. |
In vivo | Diflunisal-mediated kinetic stabilization of TTR(Rate-limiting transthyretin) should ameliorate TTR amyloidoses, provided that the nonsteroidal anti-inflammatory drug liabilities can be managed clinically[3]. |
Cell Research | HEK293T cells are transfected with expression vectors for WT p300 or catalitycally inactive mutant. 24 hr after transfection, cells are treated with diflunisal as indicated for 24 hr. H2B acetylation is measured by Western Blot using specified antibodies. Experiments are repeated four times. (Only for Reference) |
Synonyms | Flovacil, Dolobid, MK-647, Fluniget, Dolobis |
Molecular Weight | 250.2 |
Formula | C13H8F2O3 |
CAS No. | 22494-42-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (199.84 mM)
Ethanol: 20 mg/mL (79.94 mM)
You can also refer to dose conversion for different animals. More
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Diflunisal 22494-42-4 Chromatin/Epigenetic Immunology/Inflammation Neuroscience COX Epigenetic Reader Domain Flovacil Cyclooxygenase Dolobid MK 647 MK-647 Fluniget Inhibitor MK647 Dolobis inhibit inhibitor