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Dictamine

Catalog No. T5746 CAS 484-29-7

Synonyms: Dictamnine, Dectamine

Dictamine (Dectamine) shows anticholinesterase, anti-inflammatory, mutagenic, and has antimicrobial activity against bacteria and fungi. It has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells.

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Dictamine, CAS 484-29-7

Pack Size	Availability	Price/USD	Quantity
20 mg	In stock	$ 82.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 98%

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Description	Dictamine (Dectamine) shows anticholinesterase, anti-inflammatory, mutagenic, and has antimicrobial activity against bacteria and fungi. It has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells.
In vitro	Dictamnine has antimicrobial activities against the model fungus Saccharomyces cerevisiae, with a minimum inhibitory concentration (MIC) value of 64 microg/ml[1].Dictamnine(Dic) induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which loss of mitochondrial membrane potential (Δψmm) was not involved. Inhibition of caspase-3 using the specific inhibitor, z-DQMD-fmk, did not attenuate Dic-induced apoptosis, implying that Dic-induced caspase-3-independent apoptosis. Combination treatment with DHA and Dic dramatically increased the apoptotic cell death compared to Dic alone. Pretreatment with z-DQMD-fmk significantly attenuated DHA and Dic co-induced apoptosis, implying that caspase-3 plays an important role in Dic and DHA co-induced cell apoptosis. Dic induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which mitochondria and caspase were not involved and DHA enhanced Dic induced A549 cell apoptosis via a caspase-dependent pathway[2].
In vivo	Dictamnine showed different anti-inflammatory effect in variety of animal models of anti-inflammatory[3].
Kinase Assay	Commercial oligonucleotide microarrays were used to determine the global transcriptional response of S. cerevisiae triggered by treatment with dictamnine. We interpreted our microarray data using the hierarchical clustering tool, T-profiler. Several major transcriptional responses were induced by dictamnine. The first was the induced environmental stress response, mainly under the control of the Msn2p and Msn4p transcription factors, and the repressed environmental stress response in genes containing the PAC (RNA polymerase A and C box) and rRPE (ribosomal RNA processing element) motifs. The second was the Upc2p-mediated response involved in lipid biosynthesis. The third comprised the PDR3- and RPN4-mediated responses involved in multidrug resistance (MDR). Finally, the TBP-mediated response was induced with dictamnine treatment. TBP is an essential general transcription factor involved in directing the transcription of genes. Quantitative real-time RT-PCR was performed on selected genes to verify the microarray results. Furthermore, morphological transitions during dictamnine exposure to S. cerevisiae L1190 (MATa/alpha) were examined, using confocal laser microscopy[1].
Animal Research	High performance centrifugal partition chromatography method was used for separation of the essential dictamnine,and anti-inflammatory effects of ethanol extracts and dictamnine were investigated by xylene-induced aruical swelling in mice and the abdominal capillary permeability in mice[3].
Source	Natural Products > Rutaceae > Dictamnus

Synonyms	Dictamnine, Dectamine
Molecular Weight	199.21
Formula	C12H9NO2
CAS No.	484-29-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (250.99 mM)

References and Literature

1. Guo N , Yu L , Meng R , et al. Global gene expression profile of Saccharomyces cerevisiae induced by dictamnine[J]. Yeast, 2008, 25(9):631-641. 2. An FF, Liu YC, Zhang WW,et al.Dihydroartemisinine enhances dictamnine-induced apoptosis via a caspase dependent pathway in human lung adenocarcinoma A549 cells[J].Asian Pac J Cancer Prev. 2013;14(10):5895-900. 3. Dong-Fang S , Mei-Zhu Z , Li-Chun Z , et al. Isolation and Anti-inflammatory Effect of Dictamnine Extracted from Dictamni Cortex[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2012.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Traditional Chinese Medicine Monomer Library Alkaloid Natural Product Library Bioactive Compounds Library Max Human Metabolite Library Chinese Pharmacopoeia Natural Product Library Food as Medicine Compound Library Anti-Bacterial Compound Library Anti-Cancer Compound Library The Yao nationality medicine Library

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Keywords

Dictamine 484-29-7 Apoptosis Microbiology/Virology Anti-infection Antifungal Antibacterial Fungal inhibit Bacterial Dictamnine Inhibitor Dectamine inhibitor

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