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Darunavir

Catalog No. T2324 CAS 206361-99-1

Synonyms: TMC114

Darunavir is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when used alone, it is administered in combination with other ANTI-HIV AGENTS.

Darunavir, CAS 206361-99-1

Pack Size	Availability	Price/USD
1 mg	In stock	30.00
2 mg	In stock	38.00
5 mg	In stock	50.00
10 mg	In stock	60.00
25 mg	In stock	92.00
50 mg	In stock	120.00
100 mg	In stock	150.00
1 mL * 10 mM (in DMSO)	In stock	60.00

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Purity 98.00%

HNMR COA

Purity 99.69%

HNMR HPLC COA

Datasheet SDS

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Darunavir is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when used alone, it is administered in combination with other ANTI-HIV AGENTS.
Targets&IC50	HIV Protease
In vivo	Vipadenant (0.3-30 mg/kg) produces a dose-dependent reduction in catalepsy. Vipadenant (10 mg/kg) does not produce any statistically significant dyskinetic episodes in 6-OHDA-lesioned rats during a 19-day dosing regimen[1]. In the mouse and rat haloperidol-induced hypolocomotion models, vipadenant has a minimum effective dose of 0.1 and 1 mg/kg, respectively. Vipadenant (3 and 10 mg/kg, p.o.) is able to increase contralateral rotations in 6-OHDA lesioned rats[2].

Synonyms	TMC114
Purity	98.00%
Molecular Weight	547.66
Formula	C27H37N3O7S
CAS No.	206361-99-1

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

Ethanol: 35 mg/mL (78.14 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Fujimoto H, et al. Biol Pharm Bull, 2009, 32(9), 1588-1593.

Related compound libraries

This product is contained In the following compound libraries：

Approved Drug Library Bioactive Compound Library Inhibitor Library Anti-infection Compound Library Protease Inhibitor Library Anti-virus Compound Library FDA-approved Drug Library Immunology/Inflammation Compound Library Anti-Metabolism Disease Compound Library Anti-aging Compound Library Drug Repurposing Library PPI Inhibitors Library Anti-COVID-19 Compound Library Drug-induced Liver Injury (DILI) Compound Library FDA Approved & Pharmacopeial Drug Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.