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DL-Homocysteine thiolactone hydrochloride

Catalog No. T5968 CAS 6038-19-3

Synonyms: DL-Homocysteinethiolactone hydrochloride

DL-Homocysteine thiolactone hydrochloride (DL-Homocysteinethiolactone hydrochloride) is a cysteine derivative that binds to and induces conformational changes in various plasma proteins, slowing coagulation and inducing oxidative stress. It decreases left ventricular systolic blood pressure and cardiac force and induces seizures in vivo.

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DL-Homocysteine thiolactone hydrochloride Chemical Structure

DL-Homocysteine thiolactone hydrochloride, CAS 6038-19-3

Pack Size	Availability	Price/USD
500 mg	In stock	$ 41.00
1 g	In stock	$ 48.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 98%

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Description	DL-Homocysteine thiolactone hydrochloride (DL-Homocysteinethiolactone hydrochloride) is a cysteine derivative that binds to and induces conformational changes in various plasma proteins, slowing coagulation and inducing oxidative stress. It decreases left ventricular systolic blood pressure and cardiac force and induces seizures in vivo.
In vitro	Acuted administration of DL-Homocysteinethiolactone hydrochloride (DL-Hcy TLHC) induces significant reduction of CF and partly of heart contractility, which confirms its cardiodepressive effect.?The simultaneous application of different inhibitors of important cardiovascular gasotransmitters with DL-Hcy TLHC shows that additional HO-1 inhibition induces more powerful effects than NOS or CSE inhibition.?The inhibition of CO production significantly increases DL-Hcy TLHC-induced effects on cardiodynamic parameters, while NOS and CSE inhibition only affects CF. Acuted administration of DL-Hcy TLHC and different gasotransmitter inhibitors does not show prooxidant potential[1].
Cell Research	Only groups of hearts in which the CPP/CF relationship was studied twice in the absence of drugs were included in the study. After perfusion in the absence of any medication (control conditions), hearts were perfused with: 10?μM DL-Homocysteinethiolactone hydrochloride (DL-Hcy TLHC); 10?μM DL-Hcy TLHC + 30?μM L-NAME (N ω-Nitro-L-arginine methyl ester, an inhibitor of NOS); 10?μM DL-Hcy TLHC + 10?μM DL-PAG (DL-Propargylglycine, an inhibitor of cystathionine gamma lyase-CSE); 10?μM DL-Hcy TLHC + 10?μM ZnPPR IX (protoporphyrin IX zinc, an inhibitor of HO-1) and compared to the respective controls[1].

Synonyms	DL-Homocysteinethiolactone hydrochloride
Molecular Weight	153.63
Formula	C4H8ClNOS
CAS No.	6038-19-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (162.74 mM)

References and Literature

1. Zivkovic V , Jakovljevic V , Pechanova O , et al. Effects of DL-Homocysteine Thiolactone on Cardiac Contractility, Coronary Flow, and Oxidative Stress Markers in the Isolated Rat Heart: The Role of Different Gasotransmitters[J]. BioMed Research International, 2013, 2013(22):318471. 2. Andrade C R D , Tirapelli C R , Haddad R , et al. Hyperhomocysteinemia induced by feeding rats diets rich in dl-homocysteine thiolactone promotes alterations on carotid reactivity independent of arterial structure[J]. 2009, 51(4):291-298.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compounds Library Max Natural Product Library Ferroptosis Compound Library RO5 Drug-like Natural Product Library HIF-1 Signaling Pathway Compound Library NO PAINS Compound Library Bioactive Compound Library Natural Product Library for HTS

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Keywords

DL-Homocysteine thiolactone hydrochloride 6038-19-3 Metabolism Endogenous Metabolite inhibit DL-Homocysteinethiolactone hydrochloride DL-Homocysteine thiolactone Inhibitor DL-Homocysteine thiolactone Hydrochloride DL Homocysteine thiolactone hydrochloride DLHomocysteine thiolactone hydrochloride DL-Homocysteinethiolactone Hydrochloride inhibitor

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