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Clonidine hydrochloride

Catalog No. T1247 CAS 4205-91-8

Synonyms: Clonidine HCl, Catapres

Clonidine hydrochloride (Catapres) is a centrally active α-adrenergic agonist used predominantly as an antihypertensive agent.

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Clonidine hydrochloride Chemical Structure

Clonidine hydrochloride, CAS 4205-91-8

Pack Size	Availability	Price/USD
50 mg	In stock	$ 38.00
100 mg	In stock	$ 54.00
200 mg	In stock	$ 67.00
500 mg	In stock	$ 143.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 100%

Purity: 99.99%

Purity: 99.8%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Clonidine hydrochloride (Catapres) is a centrally active α-adrenergic agonist used predominantly as an antihypertensive agent.
In vitro	Clonidine, at concentrations of 0.01, 0.1, or 1 μM, significantly elevates CGRP (α and β) mRNA expression in endothelial cells in a dose-dependent manner. Additionally, a 24-hour treatment with 1 μM clonidine notably augments NO levels in these cells. This indicates that the NO pathway plays a crucial role in modulating the clonidine-induced CGRP production[2].
In vivo	Administered intraperitoneally at a dose of 50 μg/kg, clonidine markedly reduces rat body temperature, peaking at 1 hour and persisting for 3 hours; this effect is notably counteracted by a pre-administration of phentolamine into the cerebral ventricles[1]. Additionally, clonidine (0.003-0.05 mg/kg, i.p.) effectively inhibits PCP-induced dopamine release in the prefrontal cortex, an effect that is blocked by the alpha-2A receptor antagonist BRL-44408[3]. In normotensive rats treated with DMSO, clonidine (0.6 μg intracisternally) does not alter blood pressure, but following central adenosine A1R inhibition with DPCPX, it significantly lowers blood pressure. Conversely, in DMSO-treated aortic-banded rats, clonidine prominently decreases blood pressure, a response that remains unchanged after DPCPX pretreatment. Additionally, in SO rats with central A1R blockage, clonidine not only reduces blood pressure but also significantly elevates pERK1/2 levels in the RVLM, an effect not observed in DMSO-pretreated SO rats. Similarly, clonidine boosts RVLM pERK1/2 levels in vehicle-treated aortic-banded rats, unaffected by DPCPX[4].

Synonyms	Clonidine HCl, Catapres
Molecular Weight	266.55
Formula	C9H10Cl3N3
CAS No.	4205-91-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 26.7 mg/mL (100 mM)

DMSO: 20 mg/mL (75 mM)

References and Literature

1. Bugajski J, et al. The involvement of central alpha-adrenergic and histamine H2-receptors in the hypothermia induced by clonidine in the rat. Neuropharmacology. 1980 Jan;19(1):9-15. 2. Zhang YM, et al. Clonidine induces calcitonin gene-related peptide expression via nitric oxide pathway in endothelial cells. Peptides. 2009 Sep;30(9):1746-52. 3. Jentsch JD, et al. Clonidine and guanfacine attenuate phencyclidine-induced dopamine overflow in rat prefrontal cortex: mediating influence of the alpha-2A adrenoceptor subtype. Brain Res. 2008 Dec 30;1246:41-6. 4. Nassar N, et al. Brainstem adenosine A1 receptor signaling masks phosphorylated extracellular signal-regulated kinase 1/2-dependent hypotensive action of clonidine in conscious normotensive rats. J Pharmacol Exp Ther. 2009 Jan;328(1):83-9. 5. Himmel H M, Faelker T M E. Pupillary function test in rat: Establishment of imaging setup and pharmacological validation within modified Irwin test. Journal of pharmacological and toxicological methods. 2019: 106588.

Citations

1. Himmel H M, Faelker T M E. Pupillary function test in rat: Establishment of imaging setup and pharmacological validation within modified Irwin test. Journal of Pharmacological and Toxicological Methods. 2019: 106588 2. Xu C, Zhou Y, Liu Y, et al.Specific pharmacological and Gi/o protein responses of some native GPCRs in neurons.Nature Communications.2024, 15(1): 1990.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library GPCR Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Neurotransmitter Receptor Compound Library FDA-Approved & Pharmacopeia Drug Library Anti-Cancer Compound Library

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Amosulalol SM-2470 Betaxolol hydrochloride Apraclonidine hydrochloride Arbutamine (4E)-SUN9221 ACTH 1-14 acetate(25696-21-3 free base) Buflomedil hydrochloride

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Keywords

Clonidine hydrochloride 4205-91-8 GPCR/G Protein Neuroscience Adrenergic Receptor Clonidine HCl inhibit Clonidine Clonidine Hydrochloride Inhibitor Catapres Beta Receptor inhibitor

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