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Chamaejasmenin B

Catalog No. TN3628 CAS 89595-71-1

Chamaejasmenin B is a compound isolated from Stellera chamaejasme L. Chamaejasmenin B has anticancer and antitumor activity, inhibiting cancer cell migration and invasion, and inhibiting tumor metastasis.Chamaejasmenin B is used in the study of cancers such as breast cancer.

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Chamaejasmenin B, CAS 89595-71-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 766.00
5 mg	In stock	$ 1,590.00
10 mg	In stock	$ 2,150.00
25 mg	In stock	$ 3,190.00
50 mg	In stock	$ 4,290.00
1 mL * 10 mM (in DMSO)	In stock	$ 1,910.00

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Purity: 97.65%

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Description

In vitro

Chamaejasmenin B exerted potent anti-proliferative effects in the 8 human solid tumor cell lines (HepG2, SMMC-7721, A549, MG63, U2OS, KHOS, HCT-116, and HeLa) with the IC50 values ranging from 1.08 to 10.8 μmol/L)) values ranged from 3.07 to 15.97 μmol/L). In the most sensitive A549 and KHOS cells, the mechanisms underlying the antiproliferative effects were characterized. The two compounds induced prominent expression of the DNA damage marker γ-H2AX as well as apoptosis. Furthermore, treatment of the cells with the two compounds caused prominent G(0)/G(1) phase arrest.[3]

Molecular Weight	570.54
Formula	C32H26O10
CAS No.	89595-71-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Li Q, et al. Chamaejasmenin B, an Inhibitor for Metastatic Outgrowth, Reversed M2-Dominant Macrophage Polarization in Breast Tumor Microenvironment. Front Immunol. 2021;12:774230. 2. Li Q, et al. Chamaejasmenin B, a novel candidate, inhibits breast tumor metastasis by rebalancing TGF-beta paradox. Oncotarget. 2016;7(30):48180-4819 3. Zhang C, Et al. In vitro anti-cancer activity of chamaejasmenin B and neochamaejasmin C isolated from the root of Stellera chamaejasme L. Acta Pharmacol Sin. 2013;34(2):262-270.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Bioactive Compound Library Anti-Cancer Compound Library Natural Product Library for HTS Selected Plant-Sourced Compound Library Flavonoid Natural Product Library Polyphenolic Natural Product Library Traditional Chinese Medicine Monomer Library Bioactive Compounds Library Max

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Chamaejasmenin B 89595-71-1 Others Chamaejasmenin A inhibitor inhibit

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