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Catalog No. T4345Cas No. 440662-09-9
CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).
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Pack SizePrice/USDAvailabilityQuantity
5 mg$30In Stock
10 mg$48In Stock
25 mg$106In Stock
50 mg$193In Stock
100 mg$287In Stock
1 mL x 10 mM (in DMSO)$31In Stock
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Related Compound Libraries of "CeMMEC1"

Product Introduction

CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).
In vitro
CeMMEC1 exhibits high affinity activity for the bromodomains of CREBBP, EP300, BRD9 and the second bromodomain of TAF1.
Kinase Assay
TAF1 binding assays are conducted using the EPIgeneous Binding Domain kit B. Binding is determined by the displacement of an acetylated biotin peptide from a GST-tagged TAF1 protein using HTRF with a Eu3+-conjugated GST antibody donor and streptavidin-conjugated acceptor. Compounds (CeMMEC1) are dispensed into assay plates, ProxiPlate-384 Plus using an Echo 525 Liquid Handler. Binding assays are conducted in a final volume of 20 μL with 5 nM TAF1-GST, 50 nM peptide (SGRGK (ac)GGK (ac)GLGK (ac)GGAK (ac)RHRK (biotin)-acid), 6.25 nM Streptavidin-XL665, 1:200 Anti-GST-Eu3+ cryptate and 0.1% DMSO. Assay reagents are dispensed into plates using a Multidrop combi and incubated at room temperature for 3 h. Fluorescence is measured using a PHERAstar microplate reader using the HTRF module with dual emission protocol (A = excitation of 320 nm, emmission of 665 nm, and B = excitation of 320 nm, emission of 620 nm). Raw data are processed to give an HTRF ratio (channel A/B × 10,000), which is used to generate IC50 curves
Cell Research
REDS3 cells were treated with CeMMEC1(10 μM) incubating for 24 hours.
AliasCeMMEC1 HCl
Chemical Properties
Molecular Weight336.34
Cas No.440662-09-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 5.63 mg/mL (16.72 mM)
Solution Preparation Table
1 mM2.9732 mL14.8659 mL29.7318 mL148.6591 mL
5 mM0.5946 mL2.9732 mL5.9464 mL29.7318 mL
10 mM0.2973 mL1.4866 mL2.9732 mL14.8659 mL


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