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Cariprazine hydrochloride

Catalog No. T8382 CAS 1083076-69-0

Synonyms: Cariprazine HCl, RGH188 hydrochloride

Cariprazine hydrochloride (RGH188 hydrochloride) is an antipsychotic drug, is a D3 and D2 receptor partial agonist((Ki of 0.085 nM and 0.49 nM, respectively)

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Cariprazine hydrochloride Chemical Structure

Cariprazine hydrochloride, CAS 1083076-69-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 30.00
10 mg	In stock	$ 47.00
25 mg	In stock	$ 76.00
50 mg	In stock	$ 116.00
100 mg	In stock	$ 173.00
500 mg	In stock	$ 428.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 100%

Biological Description

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Description	Cariprazine hydrochloride (RGH188 hydrochloride) is an antipsychotic drug, is a D3 and D2 receptor partial agonist((Ki of 0.085 nM and 0.49 nM, respectively)
Targets&IC50	D2 receptor:0.49 nM (Ki) , 5-HT1A receptor:2.6 nM (Ki), D3 receptor:0.085 nM (Ki)
In vivo	Cariprazine occupied D(2)/D(3) receptors in a dose-dependent and saturable manner, with the lowest dose occupying ~5% of receptors and the highest dose showing more than 90% occupancy. 5-HT(1A) receptor occupancy was considerably lower compared with D(2)/D(3) occupancy at the same doses, with a maximal value of ~30% for the raphe nuclei[1].
Animal Research	Three monkeys using the following PET radioligands: [(11)C]MNPA (an agonist at D(2) and D(3) receptors), [(11)C]raclopride (an antagonist at D(2) and D(3) receptors), and [(11)C]WAY-100635 (an antagonist at 5-HT(1A) receptors). During each experimental day, the first PET measurement was a baseline study, the second after a low dose of cariprazine, and the third after the administration of a high dose[1].

Synonyms	Cariprazine HCl, RGH188 hydrochloride
Molecular Weight	463.87
Formula	C21H33Cl3N4O
CAS No.	1083076-69-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 6.67 mg/mL (14.38 mM), Sonication is recommended.

References and Literature

1. Seneca N, et al. Occupancy of dopamine D2 and D3 and serotonin 5-HT1A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography. Psychopharmacology (Berl). 2011 Dec;218(3):579-8 2. Błażej, Misiak, Przemysław,et al. Cariprazine - a novel antipsychotic drug and its place in the treatment of schizophrenia.[J]. Psychiatria polska, 2018.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Anti-Neurodegenerative Disease Compound Library GPCR Compound Library Membrane Protein-targeted Compound Library Anti-Cancer Drug Library EMA Approved Drug Library Angiogenesis related Compound Library Serotonin Receptor-Targeted Compound Library

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Keywords

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