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Carbenoxolone

Catalog No. T7732 CAS 5697-56-3

Synonyms: Biogastrone, Bioral, Carbenoxolona

Carbenoxolone is an inhibitor of 11β-HSD and gap junction connexin channels. Carbenoxolone inhibits macrophage migration into atria and prevents the development of fatty liver disease.

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Carbenoxolone, CAS 5697-56-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Carbenoxolone is an inhibitor of 11β-HSD and gap junction connexin channels. Carbenoxolone inhibits macrophage migration into atria and prevents the development of fatty liver disease.

Synonyms	Biogastrone, Bioral, Carbenoxolona
Molecular Weight	570.76
Formula	C34H50O7
CAS No.	5697-56-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: Soluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Azarashvili T, et al. Carbenoxolone induces permeability transition pore opening in rat mitochondria via the translocator protein TSPO and connexin43. Arch Biochem Biophys. 2014 Sep 15;558:87-94. 2. Franco-Pérez J, et al. Unilateral microinjection of carbenoxolone into the pontis caudalis nucleus inhibits the pentylenetetrazole-induced epileptiform activity in rats. Neurosci Lett. 2015 Aug 18;602:38-43. 3. Al-Bader MD, Jasem SA, Kilarkaje N. Carbenoxolone exposure during late gestation in rats alters placental expressions of p53 and estrogen receptors. Eur J Pharmacol. 2016 Nov 15;791:675-685. 4. Kim J, Jung EJ, Moon SS, Seo M. Protective effect of carbenoxolone on ER stress-induced cell death in hypothalamic neurons. Biochem Biophys Res Commun. 2015 Dec 25;468(4):793-9.

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TAT-Gap19 acetate Gap19 Gap 27 Carbenoxolone Gap 26 Danegaptide Hydrochloride Rotigaptide TFA(355151-12-1 free base) Larazotide acetate

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Carbenoxolone 5697-56-3 代谢细胞骨架 Gap Junction Protein Dehydrogenase Bioral Carbenoxolona Biogastrone Inhibitor inhibitor inhibit

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