Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cabotegravir (S/GSK1265744) (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (IC50: 3.0 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 46.00 | |
25 mg | In stock | $ 89.00 | |
50 mg | In stock | $ 158.00 | |
100 mg | In stock | $ 198.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 51.00 |
Description | Cabotegravir (S/GSK1265744) (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (IC50: 3.0 nM). |
Targets&IC50 | HIV-1:3.0 nM |
In vivo | GSK1265744 (50 mg/kg) effectively prevents high-dose SHIV infection in rhesus macaques. |
Kinase Assay | In vitro strand transfer assay: The inhibitory concentrations of GSK1265744 is measured in a strand transfer assay using recombinant HIV IN. A complex of integrase and biotinylated donor DNA–streptavidin-coated SPA beads is formed by incubating 2 μM purified recombinant integrase with 0.66 μM biotinylated donor DNA–4 mg/mL streptavidin-coated SPA beads in 25 mM sodium MOPS pH 7.2, 23 mM NaCl, and 10 mM MgCl2 for 5 minutes at 37°C. These beads are spun down and preincubated with diluted INSTIs for 60 minutes at 37°C. Next, [3H]-labeled target DNA substrate is added to give a final concentration of 7 nM substrate, and the strand transfer reaction is incubated at 37°C for 25 to 45 minutes, which allowed for a linear increase in strand transfer of donor DNA to radiolabeled target DNA. The signal is read using a Wallac MicroBeta scintillation plate reader. |
Synonyms | GSK744, GSK-1265744, S/GSK1265744 |
Molecular Weight | 405.35 |
Formula | C19H17F2N3O5 |
CAS No. | 1051375-10-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 36 mg/mL (88.8 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Cabotegravir 1051375-10-0 Microbiology/Virology Proteases/Proteasome HIV Protease Human immunodeficiency virus inhibit GSK744 GSK-1265744 HIV Integrase GSK-744 UGT1A1 OAT GSK 1265744 HIV S/GSK-1265744 Inhibitor S/GSK1265744 AIDS antiretroviral GSK1265744 GSK 744 S/GSK 1265744 inhibitor