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CVT-10216

Catalog No. T15022 CAS 1005334-57-5

CVT-10216 is a Potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50: 29 nM). CVT-10216 also has inhibitory effect of ALDH-1 (IC50: 1.3 μM). CVT-10216 can reduce excessive alcohol drinking in alcohol-preferring rats and exhibit anxiolytic effects.

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CVT-10216, CAS 1005334-57-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 43.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 176.00
25 mg	In stock	$ 355.00
50 mg	In stock	$ 568.00
100 mg	In stock	$ 813.00
1 mL * 10 mM (in DMSO)	In stock	$ 112.00

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Purity: 99.16%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CVT-10216 is a Potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50: 29 nM). CVT-10216 also has inhibitory effect of ALDH-1 (IC50: 1.3 μM). CVT-10216 can reduce excessive alcohol drinking in alcohol-preferring rats and exhibit anxiolytic effects.
Targets&IC50	ALDH2:29 nM
In vivo	CVT-10216 is a highly selective, reversible inhibitor of ALDH-2 that reduces excessive alcohol drinking.?Anxiety plays a role in alcoholism. As reflected in social interaction behavior in four unrelated rodent models: endogenous anxiety-like behavior in na?ve Fawn-Hooded rats, repeated alcohol-withdrawal-induced anxiety, restraint stress-induced anxiety and drug-induced anxiety.?CVT-10216 counteracted anxiety in all models except that produced by the 5-HT(2C) agonist, mCPP.?CVT-10216 exhibited both acute and prophylactic inhibitions of repeated alcohol-withdrawal-induced anxiety.?Importantly, anxiogenic behavior induced by the benzodiazepine receptor inverse agonist, DMCM, was counteracted dose-dependently by CVT-10216.CVT-10216 (intraperitoneal injection; 3.75 or 15 mg/kg) are determined 5 h into the third withdrawal, it has the anxiolytic effect of 15 mg/kg CVT-10216 in this model. ?However it has no significant effects on locomotor activity. CVT-10216 (intraperitoneal injection; 3.75, 7.5, or 15 mg/kg) shows a increase in social interaction as a dose-dependent manner, punctuated by a 2-fold increase in social interaction after 15 mg/kg in Fawn-Hooded rats[1].

Molecular Weight	465.48
Formula	C24H19NO7S
CAS No.	1005334-57-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMF: 25 mg/mL (53.71 mM), Sonication and heating are recommended.

DMSO: 20 mg/mL (42.97 mM), Sonication and heating are recommended.

References and Literature

1. Overstreet DH, et al. A selective ALDH-2 inhibitor reduces anxiety in rats.Pharmacol Biochem Behav. 2009 Dec;94(2):255-61.

Related compound libraries

This product is contained In the following compound libraries：

Highly Selective Inhibitor Library Inhibitor Library Metabolism Compound Library Glutamine Metabolism Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Bioactive Compound Library Anti-Metabolism Disease Compound Library ReFRAME Related Library Anti-Cancer Metabolism Compound Library

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Keywords

CVT-10216 1005334-57-5 Metabolism Dehydrogenase anxiolytic CVT 10216 inhibit Aldehyde Dehydrogenase (ALDH) alcohol-preferring CVT10216 Inhibitor social interaction inhibitor

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