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CVN424

Catalog No. T9346   CAS 2254706-21-1

CVN424 is a selective and novel GPR6 Inverse agonist effective in models of Parkinson Disease.

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CVN424 Chemical Structure
CVN424, CAS 2254706-21-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 97.00
5 mg In stock $ 255.00
10 mg In stock $ 396.00
25 mg In stock $ 663.00
50 mg In stock $ 945.00
100 mg In stock $ 1,280.00
1 mL * 10 mM (in DMSO) In stock $ 266.00
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Purity: 98.8%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description CVN424 is a selective and novel GPR6 Inverse agonist effective in models of Parkinson Disease.
In vivo CVN424 is brain-penetrant and shows dose-dependent receptor occupancy that attained brain 50% of receptor occupancy at plasma concentrations of 6.0 and 7.4 ng/ml in mice and rats, respectively[1].
Molecular Weight 473.52
Formula C24H29F2N5O3
CAS No. 2254706-21-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60mg/mL (126.71 mM)

TargetMolReferences and Literature

1. Nicola L Brice, et al. Development of CVN424: A Selective and Novel GPR6 Inverse Agonist Effective in Models of Parkinson Disease. J Pharmacol Exp Ther. 2021 Jun;377(3):407-416.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library GPCR Compound Library NO PAINS Compound Library Clinical Compound Library Ion Channel Inhibitor Library Covalent Inhibitor Library Bioactive Compound Library Drug Repurposing Compound Library Bioactive Compounds Library Max

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Keywords

CVN424 2254706-21-1 Endocrinology/Hormones GPCR/G Protein GPR penetrant GPR6 inhibit orally brain Inhibitor CVN 424 Parkinson disease CVN-424 inhibitor

 

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