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CRT0066854 hydrochloride

Catalog No. T10888   CAS 2250019-91-9

CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively.

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CRT0066854 hydrochloride Chemical Structure
CRT0066854 hydrochloride, CAS 2250019-91-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 98.00
5 mg In stock $ 221.00
10 mg In stock $ 272.00
25 mg In stock $ 597.00
50 mg In stock $ 852.00
100 mg In stock $ 1,170.00
500 mg In stock $ 2,350.00
1 mL * 10 mM (in DMSO) In stock $ 282.00
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Purity: 97.51%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively.
Targets&IC50 ROCKII:620 nM, PKCζ:639 nM
In vitro CRT0066854 hydrochloride replaces the crucial Asn-Phe-Asp motif, which is part of the adenosine binding pocket and joins with the acidic patch used by the PKC substrate rich in arginine. CRT0066854 hydrochloric acid Salt (0.2-1.2μM; 6 days) can restore polarized morphogenesis. Among the dysplastic H-Ras spheroids, the maximum proportion of PSAL spheroids was 1.2 μM at a lower dose[1].
Molecular Weight 488.48
Formula C24H27Cl2N5S
CAS No. 2250019-91-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (92.12 mM)

TargetMolReferences and Literature

1. Kjær S, et al. Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes. Biochem J. 2013 Apr 15;451(2):329-42.

Related compound libraries

This product is contained In the following compound libraries:
TGF-beta/Smad Compound Library Inhibitor Library Bioactive Compounds Library Max Cytoskeletal Signaling Pathway Compound Library Anti-Cancer Compound Library Bioactive Compound Library Epigenetics Compound Library

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Keywords

CRT0066854 hydrochloride 2250019-91-9 Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling Stem Cells PKC ROCK CRT 0066854 Hydrochloride CRT-0066854 Hydrochloride CRT-0066854 hydrochloride CRT0066854 Hydrochloride inhibitor inhibit

 

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