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CRA-026440

Catalog No. T10883 CAS 847460-34-8

Synonyms: PCI-34051

CRA-026440(PCI-34051) is a highly potent HDAC inhibitor with inhibitory effects on HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 and HDAC10 with Ki values of 4,14,11,15,7 and 20 nM, respectively. CRA-026440 has anti-tumor and anti-angiogenic activity and can be used to study colon cancer.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

CRA-026440, CAS 847460-34-8

Pack Size	Availability	Price/USD	Quantity
1 mg	6-8 weeks	$ 700.00
5 mg	6-8 weeks	$ 1,800.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Purity: 96.42%

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Description	CRA-026440(PCI-34051) is a highly potent HDAC inhibitor with inhibitory effects on HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 and HDAC10 with Ki values of 4,14,11,15,7 and 20 nM, respectively. CRA-026440 has anti-tumor and anti-angiogenic activity and can be used to study colon cancer.
Targets&IC50	HDAC10:20 nM (Ki), HDAC6:15 nM (ki), HDAC8:7 nM (ki), HDAC1:4 nM (ki), HDAC3:11 nM (ki), HDAC2:14 nM (ki)
In vitro	CRA-026440 exhibits anti-proliferative effects on HUVEC endothelial cells with a GI50 value of 1.41 μM[1]. In tumor cells, treatment with CRA-026440 (0.1-10 μM; 18 hours) leads to the accumulation of acetylated histones and acetylated microtubule proteins, thereby inhibiting tumor cell growth and inducing apoptosis[1]. CRA-026440 (0.1-10 μM; 5 days) inhibits ex vivo angiogenesis in a dose-dependent manner[1].
In vivo	Administered intravenously at a dose of 100 mg/kg daily for three consecutive days, CRA-026440 significantly reduces tumor growth in mice bearing HCT116 or U937 human tumor xenografts[1].

Synonyms	PCI-34051
Molecular Weight	420.46
Formula	C23H24N4O4
CAS No.	847460-34-8

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90 mg/mL (214.05 mM), Sonication is recommended.

References and Literature

1. Cao ZA, et al. CRA-026440: a potent, broad-spectrum, hydroxamic histone deacetylase inhibitor with antiproliferative and antiangiogenic activity in vitro and in vivo. Mol Cancer Ther. 2006 Jul;5(7):1693-701.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CRA-026440 847460-34-8 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC PCI-34051 CRA 026440 CRA026440 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.