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Ocifisertib（CFI-400945 free base）

Catalog No. T7384 CAS 1338806-73-7

CFI-400945 is an potent, selective and orally active inhibitor of polo-like kinase 4(PLK4; Ki value of 0.26 nM).

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Ocifisertib（CFI-400945 free base） Chemical Structure

Ocifisertib（CFI-400945 free base）, CAS 1338806-73-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 59.00
2 mg	In stock	$ 86.00
5 mg	In stock	$ 143.00
10 mg	In stock	$ 228.00
25 mg	In stock	$ 441.00
50 mg	In stock	$ 649.00
100 mg	In stock	$ 926.00
1 mL * 10 mM (in DMSO)	In stock	$ 255.00

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Purity: 98.53%

Purity: 97.56%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CFI-400945 is an potent, selective and orally active inhibitor of polo-like kinase 4(PLK4; Ki value of 0.26 nM).
Targets&IC50	PLK4:0.26 nM(ki)
In vitro	CFI-400945, a potent and selective PLK4 inhibitor.?Cancer cells treated with CFI-400945 exhibit effects consistent with PLK4 kinase inhibition, including dysregulated centriole duplication, mitotic defects, and cell death[1].
In vivo	Oral administration of CFI-400945 to mice bearing human cancer xenografts results in the significant inhibition of tumor growth at doses that are well tolerated[1].

Molecular Weight	534.65
Formula	C33H34N4O3
CAS No.	1338806-73-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 100 mg/mL (187.04 mM)

H2O: Insoluble

DMSO: 100 mg/mL (187.04 mM), Heating to 50℃ is recommended.

References and Literature

1. Mason J , Lin D C , Wei X , et al. Functional Characterization of CFI-400945, a Polo-like Kinase 4 Inhibitor, as a Potential Anticancer Agent[J]. Cancer Cell, 2014, 26(2). 2. Veitch Z W , Cescon D W , Denny T , et al. Safety and tolerability of CFI-400945, a first-in-class, selective PLK4 inhibitor in advanced solid tumours: a phase 1 dose-escalation trial[J]. British Journal of Cancer, 2019, 121(4):318-324.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Drug Repurposing Compound Library ReFRAME Related Library Orally Active Compound Library Kinase Inhibitor Library Anti-Cancer Compound Library Bioactive Compounds Library Max Cell Cycle Compound Library Bioactive Compound Library

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Related compounds with same targets

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ocifisertib（CFI-400945 free base） 1338806-73-7 Cell Cycle/Checkpoint PLK CFI400945 free base CFI-400945 Ocifisertib CFI-400945 free base CFI 400945 free base CFI400945 CFI 400945 inhibitor inhibit

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