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CAY10640

Catalog No. T38367 CAS 1208549-68-1

Synonyms: sEH inhibitor-1

CAY10640 (sEH inhibitor-1) is a potent, orally active, water-soluble epoxide hydrolase (sEH) inhibitor that inhibits sEH in humans and mice with IC50s of 0.4 and 5.3 nM, respectively.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

CAY10640, CAS 1208549-68-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 178.00
5 mg	In stock	$ 445.00
10 mg	In stock	$ 656.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,400.00
100 mg	In stock	$ 1,880.00
500 mg	In stock	$ 3,780.00

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Purity: 99.17%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CAY10640 (sEH inhibitor-1) is a potent, orally active, water-soluble epoxide hydrolase (sEH) inhibitor that inhibits sEH in humans and mice with IC50s of 0.4 and 5.3 nM, respectively.
Targets&IC50	sEH (mouse):0.4 nM
In vivo	Oral administration of 13 1-aryl-3-(1-acylpiperidin-4-yl)urea (CAY10640) inhibitors in mice revealed substantial improvements in pharmacokinetic parameters over previously reported 1-adamantylurea based inhibitors. This novel sEH inhibitor showed a 1000-fold increase in potency when compared to morphine by reducing hyperalgesia as measured by mechanical withdrawal threshold using the in vivo carrageenan induced inflammatory pain model.[1]

Synonyms	sEH inhibitor-1
Molecular Weight	371.35
Formula	C17H20F3N3O3
CAS No.	1208549-68-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMF: 4.5 mg/mL (12.2 mM)

Ethanol: 2 mg/mL

DMSO: 4.5 mg/mL (12.2 mM)

References and Literature

1. Rose TE,et al. 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain. J Med Chem. 2010;53(19):7067-7075.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library

Related Products

Related compounds with same targets

Valpromide VU534 beta-Amyrin acetate GSK2256294A AR-9281 ARM1 sEH inhibitor-7 Diflapolin

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CAY10640 1208549-68-1 Metabolism Epoxide Hydrolase CAY 10640 sEH inhibitor-1 CAY-10640 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.