Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Bumetanide is a potent sulfamoylanthranilic acid derivative belonging to the class of loop diuretics. In the brain, bumetanide may prevent seizures in neonates by blocking the bumetanide-sensitive sodium-potassium-chloride cotransporter (NKCC1), thereby inhibiting chloride uptake thus, decreasing the internal chloride concentration in neurons and may block the excitatory effect of GABA in neonates.
Description | Bumetanide is a potent sulfamoylanthranilic acid derivative belonging to the class of loop diuretics. In the brain, bumetanide may prevent seizures in neonates by blocking the bumetanide-sensitive sodium-potassium-chloride cotransporter (NKCC1), thereby inhibiting chloride uptake thus, decreasing the internal chloride concentration in neurons and may block the excitatory effect of GABA in neonates. |
Targets&IC50 | hNKCC1A:0.68 μM, hNKCC2A:4.0 μM |
Synonyms | PF 1593, Ro 10-6338 |
Molecular Weight | 364.42 |
Formula | C17H20N2O5S |
CAS No. | 28395-03-1 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 36.4 mg/mL (100 mM)
Ethanol: 27.3 mg/mL (75 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Bumetanide 28395-03-1 Membrane transporter/Ion channel Na-K-Cl cotransporter PF 1593 PF-1593 artery cotransporter diuretic inhibit NKCC2 PF1593 cerebral Ro 10-6338 neonatal MCAO NKCC1 seizures NKCC occlusion Inhibitor middle inhibitor