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Bumetanide

Catalog No. T0108 CAS 28395-03-1

Synonyms: PF 1593, Ro 10-6338

Bumetanide is a potent sulfamoylanthranilic acid derivative belonging to the class of loop diuretics. In the brain, bumetanide may prevent seizures in neonates by blocking the bumetanide-sensitive sodium-potassium-chloride cotransporter (NKCC1), thereby inhibiting chloride uptake thus, decreasing the internal chloride concentration in neurons and may block the excitatory effect of GABA in neonates.

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Bumetanide, CAS 28395-03-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Targets&IC50

hNKCC1A:0.68 μM, hNKCC2A:4.0 μM

Synonyms	PF 1593, Ro 10-6338
Molecular Weight	364.42
Formula	C17H20N2O5S
CAS No.	28395-03-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 36.4 mg/mL (100 mM)

Ethanol: 27.3 mg/mL (75 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Thakker RV. Adv Nephrol Necker Hosp. 1999;29:289-98.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Inhibitor Library Ion Channel Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library FDA-Approved Drug Library Kinase Inhibitor Library Approved Drug Library Anti-Cancer Drug Library FDA-Approved & Pharmacopeia Drug Library

Related Products

Related compounds with same targets

Furosemide sodium Torsemide Azosemide Furosemide

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Bumetanide 28395-03-1 Membrane transporter/Ion channel Na-K-Cl cotransporter PF 1593 PF-1593 artery cotransporter diuretic inhibit NKCC2 PF1593 cerebral Ro 10-6338 neonatal MCAO NKCC1 seizures NKCC occlusion Inhibitor middle inhibitor

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