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BMS-817399

Catalog No. T26861 CAS 1202400-18-7

Synonyms: BMS817399

BMS-817399 is an orally active antagonist of CCR1 with IC50s of binding affinity and chemotaxis inhibition potencies and can be used in studies about rheumatoid arthritis.

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BMS-817399, CAS 1202400-18-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BMS-817399 is an orally active antagonist of CCR1 with IC50s of binding affinity and chemotaxis inhibition potencies and can be used in studies about rheumatoid arthritis.
Targets&IC50	CCR1:1 nM (IC50)

Synonyms	BMS817399
Molecular Weight	454
Formula	C23H36ClN3O4
CAS No.	1202400-18-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 55 mg/mL (121.14 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Chen H, et al. Moisture-Induced Amorphous Phase Separation of Amorphous Solid Dispersions: Molecular Mechanism, Microstructure, and Its Impact on Dissolution Performance. J Pharm Sci. 2018 Jan;107(1):317-326. 2. Khan JA, et al. Developing Adnectins that target SRC co-activator binding to PXR: a structural approach toward understanding promiscuity of PXR. J Mol Biol. 2015 Feb 27;427(4):924-42. 3. Santella JB 3rd, et al. Discovery of the CCR1 antagonist, BMS-817399, for the treatment of rheumatoid arthritis. J Med Chem. 2014;57(18):7550-7564.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BMS-817399 1202400-18-7 Immunology/Inflammation Microbiology/Virology CCR BMS 817399 BMS817399 Inhibitor inhibitor inhibit

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