Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays < 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 30.00 | |
5 mg | In stock | $ 63.00 | |
10 mg | In stock | $ 107.00 | |
25 mg | In stock | $ 235.00 | |
50 mg | In stock | $ 387.00 | |
100 mg | In stock | $ 541.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 63.00 |
Description | BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K. |
Targets&IC50 | JNK:280 nM |
In vitro | BI-78D3 Inhibits JNK interacting protein 1 (JIP1)-JNK binding and prevents JNK substrate phosphorylation[2]. |
In vivo | In animal studies, BI-78D3 not only blocks JNK dependent Con A-induced liver damage but also restores insulin sensitivity in mouse models of type 2 diabetes[1]. |
Cell Research | Cells are subjected to a dose range of doxorubicin concentrations in the presence or absence of a non-toxic dose (10 nM) of the small molecule JIP1-inhibitor BI-78D3. (Only for Reference) |
Molecular Weight | 379.37 |
Formula | C13H9N5O5S2 |
CAS No. | 883065-90-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 1.9 mg/mL (5 mM)
DMSO: 37.9 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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BI-78D3 883065-90-5 MAPK JNK BI-78D-3 inhibit BI 78D3 Inhibitor BI78D3 inhibitor