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Azithromycin hydrate

Catalog No. T1419 CAS 117772-70-0

Synonyms: Azithromycin dihydrate, CP-62993 dihydrate

Azithromycin dihydrate is a semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.

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Azithromycin hydrate, CAS 117772-70-0

Pack Size	Availability	Price/USD	Quantity
20 mg	In stock	$ 50.00
1 mL * 10 mM (in DMSO)	In stock	$ 60.00

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Purity: 99.9%

Purity: 99.83%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Azithromycin dihydrate is a semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.
In vivo	Azithromycin (50 mg/kg) has no effect on bronchoalveolar lavage inflammatory parameters and LDH levels in a mouse model of asthma exacerbation. Azithromycin induces neither general inflammatory parameters nor LDH release in a mouse model of asthma exacerbation, and augments expression of interferon-stimulated genes and the pattern recognition receptor MDA5 which is sufficient to reduce viral load, but not RIG-I in exacerbating mice[2].
Cell Research	THP-1 cells (106 cells in 1 mL RPMI medium, without antibiotics, growth factors or serum) are seeded in each well of 24-well plates and allowed to settle for 1 hour. Next, 50 μL of the test compound is added followed by 50 μL of LPS (final concentration of 10 μg/mL). After 24h (37°C and 5% CO2) the supernatants and cell pellets are collected (1200 rpm, 5 min). THP-1 cell viability is tested using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). MTT is dissolved at 2 mg/mL in PBS and aliquots are stored at -20°C. The MTT assay is performed according to the suppliers instructions. Absorbance of MTT converted into formazan is measured at a wavelength of 570 nm with background subtraction at 630 nm.

Synonyms	Azithromycin dihydrate, CP-62993 dihydrate
Molecular Weight	785.03
Formula	C38H72N2O12·2H2O
CAS No.	117772-70-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

H2O: 10 mg/mL (12.73 mM)

DMSO: 93 mg/mL (118.5 mM)

Ethanol: 93 mg/mL (118.5 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Peters DH, et al. Drugs, 1992, 44(5), 750-799. 2. Menzel M, et al. Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. Oncotarget. 2017 Mar 18.

Related compound libraries

This product is contained In the following compound libraries：

FDA-Approved Drug Library NO PAINS Compound Library Drug Repurposing Compound Library Microbial Natural Product Library Antibiotics Library Covalent Inhibitor Library Anti-Cancer Compound Library Anti-Cancer Clinical Compound Library Clinical Compound Library Autophagy Compound Library

Related Products

Related compounds with same targets

Tigecycline Clarithromycin Doxycycline Puromycin dihydrochloride Lincomycin hydrochloride monohydrate Chloramphenicol Kanamycin sulfate Neomycin sulfate

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Azithromycin hydrate 117772-70-0 Autophagy Microbiology/Virology ribosome Antibacterial Antibiotic Azithromycin inhibit Azithromycin dihydrate CP-62993 dihydrate Bacterial Inhibitor inhibitor

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