Powder: -20°C for 3 years | In solvent: -80°C for 2 years
Azithromycin dihydrate is a semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
20 mg | In stock | $ 50.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 60.00 |
Description | Azithromycin dihydrate is a semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis. |
In vivo | Azithromycin (50 mg/kg) has no effect on bronchoalveolar lavage inflammatory parameters and LDH levels in a mouse model of asthma exacerbation. Azithromycin induces neither general inflammatory parameters nor LDH release in a mouse model of asthma exacerbation, and augments expression of interferon-stimulated genes and the pattern recognition receptor MDA5 which is sufficient to reduce viral load, but not RIG-I in exacerbating mice[2]. |
Cell Research | THP-1 cells (106 cells in 1 mL RPMI medium, without antibiotics, growth factors or serum) are seeded in each well of 24-well plates and allowed to settle for 1 hour. Next, 50 μL of the test compound is added followed by 50 μL of LPS (final concentration of 10 μg/mL). After 24h (37°C and 5% CO2) the supernatants and cell pellets are collected (1200 rpm, 5 min). THP-1 cell viability is tested using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). MTT is dissolved at 2 mg/mL in PBS and aliquots are stored at -20°C. The MTT assay is performed according to the suppliers instructions. Absorbance of MTT converted into formazan is measured at a wavelength of 570 nm with background subtraction at 630 nm. |
Synonyms | Azithromycin dihydrate, CP-62993 dihydrate |
Molecular Weight | 785.03 |
Formula | C38H72N2O12·2H2O |
CAS No. | 117772-70-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
H2O: 10 mg/mL (12.73 mM)
DMSO: 93 mg/mL (118.5 mM)
Ethanol: 93 mg/mL (118.5 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Azithromycin hydrate 117772-70-0 Autophagy Microbiology/Virology ribosome Antibacterial Antibiotic Azithromycin inhibit Azithromycin dihydrate CP-62993 dihydrate Bacterial Inhibitor inhibitor