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Atomoxetine

Catalog No. T20886 CAS 83015-26-3

Synonyms: Tomoxetine, HSDB7352, HSDB-7352, HSDB 7352

Atomoxetine (HSDB 7352) is a selective norepinephrine inhibitor that may cause an increase in blood pressure by increasing norepinephrine concentrations in peripheral sympathetic neurons .Atomoxetine is a highly selective antagonist of presynaptic norepinephrine transporters with little or no affinity for other norepinephrine receptors or other neurotransmitter transporters or receptors, but has little or no affinity for 5- hydroxytryptamine transporter. Atomoxetine selectively inhibits reuptake of norepinephrine and can be used to treat adolescents with ADHD and chronic tics.

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Atomoxetine, CAS 83015-26-3

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25 mg	6-8 weeks	$ 1,520.00

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Description	Atomoxetine (HSDB 7352) is a selective norepinephrine inhibitor that may cause an increase in blood pressure by increasing norepinephrine concentrations in peripheral sympathetic neurons .Atomoxetine is a highly selective antagonist of presynaptic norepinephrine transporters with little or no affinity for other norepinephrine receptors or other neurotransmitter transporters or receptors, but has little or no affinity for 5- hydroxytryptamine transporter. Atomoxetine selectively inhibits reuptake of norepinephrine and can be used to treat adolescents with ADHD and chronic tics.
Targets&IC50	Norepinephrine:5 nM, 5-HT:77 nM, Dopamine:1451 nM
In vitro	Atomoxetine (Tomoxetine) exhibits state- and dose-dependent interaction with the human cardiac sodium channel (hNav1.5) in tsA201 cells, with concentrations ranging from 1 to 100 µM and exposure durations of 0.5 to 20 seconds.[2]
In vivo	Administration of Atomoxetine (Tomoxetine) at doses of 0.3-3 mg/kg (i.p.) for a duration of 0-4 hours in male Sprague-Dawley rats results in a threefold increase in extracellular norepinephrine and dopamine levels, along with an increase in Fos expression observed in the prefrontal cortex.[1] Furthermore, Atomoxetine (Tomoxetine) at doses of 0.1-5 mg/kg (i.p. and p.o.) administered over a period of 14 days in spontaneously hypertensive rats demonstrates the potential to ameliorate ADHD-related behaviors in rats.[3]

Synonyms	Tomoxetine, HSDB7352, HSDB-7352, HSDB 7352
Molecular Weight	255.35
Formula	C17H21NO
CAS No.	83015-26-3

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

References and Literature

1. Turner M, et al. Effects of atomoxetine on locomotor activity and impulsivity in the spontaneously hypertensive rat. Behav Brain Res. 2013;243:28-37. 2. Föhr KJ, et al. Block of Voltage-Gated Sodium Channels by Atomoxetine in a State- and Use-dependent Manner. Front Pharmacol. 2021;12:622489. 3. Bymaster FP, et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002;27(5):699-711. 4. Mosholder AD, et al. Incidence of Heart Failure and Cardiomyopathy Following Initiation of Medications for Attention-Deficit/Hyperactivity Disorder: A Descriptive Study. J Clin Psychopharmacol. 2018;38(5):505-508. 5. Cortese S, et al. Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis. Lancet Psychiatry. 2018;5(9):727-738. 6. Froehlich T, et al. Using ADHD Medications to Treat Coexisting ADHD and Reading Disorders: A Systematic Review. Clin Pharmacol Ther. 2018;104(4):619-637. 7. van den Brink RL, et al. Amplification and Suppression of Distinct Brain-wide Activity Patterns by Catecholamines. Journal of Neuroscience. 2018;38(34): 7476-7491.

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Keywords

Atomoxetine 83015-26-3 Neuroscience Norepinephrine Tomoxetine HSDB7352 HSDB-7352 HSDB 7352 inhibitor inhibit

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