Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Atipamezole is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. Atipamezole hydrochloride (MPV-1248 hydrochloride) is hydrochloride form of atipamezole.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 47.00 | |
10 mg | In stock | $ 68.00 | |
25 mg | In stock | $ 135.00 | |
50 mg | In stock | $ 243.00 | |
100 mg | In stock | $ 360.00 | |
200 mg | In stock | $ 563.00 | |
500 mg | In stock | $ 888.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 52.00 |
Description | Atipamezole is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. Atipamezole hydrochloride (MPV-1248 hydrochloride) is hydrochloride form of atipamezole. |
Targets&IC50 | α2-adrenoceptor antagonist:1.6 nM(Ki). |
In vitro | The affinity of atipamezole for α2-adrenoceptors and its α2/α1 selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α2-adrenoceptors. It has negligible affinity for 5-HT1, 5-HT2 and I2 bindings sites[1]. |
In vivo | Atipamezole is well tolerated in rodents. The cardiovascular effects of atipamezole (0.01–1 mg/kg, i.v.) are rather modest in anesthetized, normotensive rats. Atipamezole is commonly used by veterinarians to awaken animals from sedation or anesthesia. Atipamezole increases sexual activity in rats and monkeys. In animals with sustained nociception, atipamezole increases pain-related responses by blocking the noradrenergic feedback inhibition of pain. Atipamezole at low doses has beneficial effects on alertness, selective attention, planning, learning, and recall in experimental animals while not necessarily on short-term working memory[1]. |
Synonyms | MPV-1248 hydrochloride, Antisedan |
Molecular Weight | 248.75 |
Formula | C14H16N2·HCl |
CAS No. | 104075-48-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 24.9 mg/mL (100 mM)
H2O: 24.9 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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Atipamezole hydrochloride 104075-48-1 GPCR/G Protein Neuroscience Adrenergic Receptor Atipamezole Hydrochloride MPV1248 Hydrochloride MPV 1248 Hydrochloride Beta Receptor MPV-1248 hydrochloride MPV 1248 Inhibitor MPV-1248 Hydrochloride MPV1248 Atipamezole inhibit Antisedan MPV-1248 inhibitor