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Catalog No. T4265   CAS 1321514-06-0
Synonyms: HTL1071

AZD4635 is a new-type adenosine 2A receptor (A2AR) inhibitor(Ki=1.7 nM).

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AZD4635, CAS 1321514-06-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 31.00
2 mg In stock $ 44.00
5 mg In stock $ 72.00
10 mg In stock $ 118.00
25 mg In stock $ 198.00
50 mg In stock $ 312.00
100 mg In stock $ 480.00
500 mg In stock $ 1,060.00
1 mL * 10 mM (in DMSO) In stock $ 79.00
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Purity: 99.61%
Purity: 99.15%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description AZD4635 is a new-type adenosine 2A receptor (A2AR) inhibitor(Ki=1.7 nM).
Targets&IC50 A2AR:Ki: 1.7 nM
Synonyms HTL1071
Molecular Weight 315.74
Formula C15H11ClFN5
CAS No. 1321514-06-0


Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 83.3 mg/mL (263.83 mM)

H2O: < 0.1 mg/mL (insoluble)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Alexandra Borodovsky, et al. Abstract 5580: PreClinicalal pharmacodynamics and antitumor activity of AZD4635, a novel adenosine 2A receptor inhibitor that reverses adenosine mediated T cell suppression. AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5580.


1. Kang G, Zhao X, Sun J, et al.A2AR limits IL-15-induced generation of CD39+ NK cells with high cytotoxicity.International Immunopharmacology.2023, 114: 109567.

Related compound libraries

This product is contained In the following compound libraries:
GPCR Compound Library Orally Active Compound Library Anti-Neurodegenerative Disease Compound Library Bioactive Compound Library Bioactive Compounds Library Max ReFRAME Related Library Anti-Cancer Compound Library Fluorochemical Library Anti-Lung Cancer Compound Library Neuronal Signaling Compound Library

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box


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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.


AZD4635 1321514-06-0 GPCR/G Protein Neuroscience Adenosine Receptor inhibit AZD 4635 Imaradenant HTL-1071 Inhibitor HTL 1071 P1 receptor AZD-4635 HTL1071 inhibitor