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AZD4635

Catalog No. T4265 CAS 1321514-06-0

Synonyms: HTL1071

AZD4635 is a new-type adenosine 2A receptor (A2AR) inhibitor(Ki=1.7 nM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

AZD4635, CAS 1321514-06-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
2 mg	In stock	$ 44.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 118.00
25 mg	In stock	$ 198.00
50 mg	In stock	$ 312.00
100 mg	In stock	$ 480.00
500 mg	In stock	$ 1,060.00
1 mL * 10 mM (in DMSO)	In stock	$ 79.00

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Purity: 99.61%

Purity: 99.15%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AZD4635 is a new-type adenosine 2A receptor (A2AR) inhibitor(Ki=1.7 nM).
Targets&IC50	A2AR:Ki: 1.7 nM

Synonyms	HTL1071
Molecular Weight	315.74
Formula	C15H11ClFN5
CAS No.	1321514-06-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 83.3 mg/mL (263.83 mM)

H2O: < 0.1 mg/mL (insoluble)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Alexandra Borodovsky, et al. Abstract 5580: PreClinicalal pharmacodynamics and antitumor activity of AZD4635, a novel adenosine 2A receptor inhibitor that reverses adenosine mediated T cell suppression. AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5580.

Citations

1. Kang G, Zhao X, Sun J, et al.A2AR limits IL-15-induced generation of CD39+ NK cells with high cytotoxicity.International Immunopharmacology.2023, 114: 109567.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Orally Active Compound Library Anti-Neurodegenerative Disease Compound Library Bioactive Compound Library Bioactive Compounds Library Max ReFRAME Related Library Anti-Cancer Compound Library Fluorochemical Library Anti-Lung Cancer Compound Library Neuronal Signaling Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AZD4635 1321514-06-0 GPCR/G Protein Neuroscience Adenosine Receptor inhibit AZD 4635 Imaradenant HTL-1071 Inhibitor HTL 1071 P1 receptor AZD-4635 HTL1071 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.