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Nebularine

Name: Nebularine
Brand: TargetMol
SKU: TNU0052
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TNU0052Cas No. 550-33-4

Alias 9-(beta-D-Ribofuranosyl)-9H-purine

Nebularine (9-(beta-D-Ribofuranosyl)-9H-purine) is a purine nucleoside analog with a broad spectrum of antitumor activity, targeting inert lymphoid malignancies and inducing apoptosis.The anticancer mechanism of Nebularine is dependent on the inhibition of DNA synthesis.

Nebularine

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Purity: 99.59%

Catalog No. TNU0052Alias 9-(beta-D-Ribofuranosyl)-9H-purineCas No. 550-33-4

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$40	-	In Stock
25 mg	$81	-	In Stock
50 mg	$129	-	In Stock
100 mg	$213	-	In Stock
200 mg	$318	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.59%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Nebularine AI Summary

Nebularine demonstrates a diverse range of biological activities. It exhibits potent anti-Herpes simplex virus type-1 activity in vero cells with an IC50 of 0.6 nM, effectively inhibiting viral replication. In mouse models, it shows significant antitumor effects against P388 tumors, with an increase in lifespan of 40.0% at 6.25 mg/kg and 60.0% at 3.13 mg/kg. Additionally, it displays differential inhibitory activity across various enzymes and cells. It inhibits mouse kidney cytidine deaminase with a Ki of 10000.0 nM and adenosine deaminase enzymes from calf intestine and calf duodenum with Ki values of 15000.0 nM and 9300.0 nM, respectively. Against mouse L929 cells, it shows cytotoxicity with an IC50 of 2370.0 nM, and it has trypanocidal activity against Trypanosoma brucei brucei with an IC50 of 1150.0 nM. Furthermore, it inhibits proliferation in various human tumor cell lines and affects multiple molecular targets, including ROR gamma, Lamin A, and Bloom's syndrome helicase, among others. Nebularine also exhibits potential as an inhibitor of tyrosyl-DNA phosphodiesterase 1 (TDP1) and may inhibit Marburg Virus and Lassa Virus entry into cells..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Nebularine (9-(beta-D-Ribofuranosyl)-9H-purine) is a purine nucleoside analog with a broad spectrum of antitumor activity, targeting inert lymphoid malignancies and inducing apoptosis.The anticancer mechanism of Nebularine is dependent on the inhibition of DNA synthesis.
Synonyms	9-(beta-D-Ribofuranosyl)-9H-purine

Chemical Properties

Molecular Weight	252.23
Formula	C₁₀H₁₂N₄O₄
Cas No.	550-33-4
Smiles	OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2cncnc12

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (218.05 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9646 mL	19.8232 mL	39.6464 mL	198.2318 mL
5 mM	0.7929 mL	3.9646 mL	7.9293 mL	39.6464 mL
10 mM	0.3965 mL	1.9823 mL	3.9646 mL	19.8232 mL
20 mM	0.1982 mL	0.9912 mL	1.9823 mL	9.9116 mL
50 mM	0.0793 mL	0.3965 mL	0.7929 mL	3.9646 mL
100 mM	0.0396 mL	0.1982 mL	0.3965 mL	1.9823 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc