7α,25-Dihydroxycholesterol
Catalog No. T14063 CAS
64907-22-8
Synonyms:
7α,25-OHC
7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells[1][2], and it is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM).
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7α,25-Dihydroxycholesterol, CAS 64907-22-8
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Biological Description
Chemical Properties
Storage
& Solubility Information
Description |
7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells[1][2], and it is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM). |
In vitro |
7α, 25-dihydroxycholesterol (7α,25-OHC) stimulates the migration of EBI2-expressing mouse B and T cells with half-maximum effective concentration values around 500 pM in vitro. However, it had no effect on EBI2-deficient cells[1]. |
In vivo |
In vivo, EBI2-deficient B cells or normal B cells desensitized by 7α,25-Dihydroxycholesterol (1 μM; 1.5 hours) pre-treatment shows reduced homing to follicular areas of the spleen[1]. |
Synonyms |
7α,25-OHC
|
Molecular Weight |
418.65
|
Formula |
C27H46O3 |
CAS No. |
64907-22-8 |
Storage
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Solubility Information
DMSO: 1 mg/mL (2.39 mM),
Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
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Keywords
7α,25-Dihydroxycholesterol
64907-22-8
G蛋白偶联受体
代谢
Endogenous Metabolite
EBI2/GPR183
endogenous
response
oxysterols
GPCR
ligand
7α,25 Dihydroxycholesterol
receptor
Inhibitor
immune
migration
7α,25Dihydroxycholesterol
cells
inhibit
inhibitor