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5,7-DIMETHOXYFLAVONE

Catalog No. T5778 CAS 21392-57-4

5,7-DIMETHOXYFLAVONE possessed remarkable leishmanicidal potential.

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5,7-DIMETHOXYFLAVONE, CAS 21392-57-4

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

5,7-DIMETHOXYFLAVONE possessed remarkable leishmanicidal potential.

In vitro

The best in vitro trypanocidal activity for T. brucei rhodesiense was exerted by 7,8-dihydroxyflavone (50% inhibitory concentration [IC50], 68 ng/ml), followed by 3-hydroxyflavone, rhamnetin, and 7,8,3',4'-tetrahydroxyflavone (IC50s, 0.5 microg/ml) and catechol (IC50, 0.8 microg/ml).?The activity against T. cruzi was moderate, and only Chrysin dimethylether and 3-hydroxydaidzein had IC50s less than 5.0 microg/ml.

Molecular Weight	282.295
Formula	C17H14O4
CAS No.	21392-57-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Tasdemir D . Antitrypanosomal and antileishmanial activites of flavoids and their analogues : In vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies[J]. Antimicrob Agents Chemother, 2006, 50(4):1352-1364.

Related compound libraries

This product is contained In the following compound libraries：

Flavonoid Natural Product Library Traditional Chinese Medicine Monomer Library Natural Product Library for HTS Anti-Aging Compound Library Bioactive Compound Library Selected Plant-Sourced Compound Library Chinese Pharmacopoeia Natural Product Library

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Keywords

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